Virally Mediated Overexpression of Glial-Derived Neurotrophic Factor Elicits Age- and Dose-Dependent Neuronal Toxicity and Hearing Loss

• Published in: Human gene therapy Vol. 30; no. 1; p. 88
• Main Authors: Akil, Omar, Blits, Bas, Lustig, Lawrence R, Leake, Patricia A
• Format: Journal Article
• Language: English
• Published: United States 01.01.2019
• Subjects: Animals; Biomarkers; Cochlea - metabolism; Cochlea - pathology; Disease Models, Animal; Fluorescent Antibody Technique; Gene Expression; Gene Transfer Techniques; Genetic Therapy - methods; Genetic Vectors - genetics; Glial Cell Line-Derived Neurotrophic Factor - genetics; Hearing Loss - diagnosis; Hearing Loss - genetics; Hearing Loss - physiopathology; Hearing Loss - therapy; Humans; Immunohistochemistry; Mice; Neurons - metabolism; Phenotype; spiral ganglion; hearing loss; auditory nerve; cochlear hair cells; adeno-associated virus vector serotype 5 (AAV-5); glial-derived neurotrophic factor (GDNF)

Contemporary cochlear implants (CI) are generally very effective for remediation of severe to profound sensorineural hearing loss, but outcomes are still highly variable. Auditory nerve survival is likely one of the major factors underlying this variability. Neurotrophin therapy therefore has been p...