Synthesis and in vitro antimycobacterial activity of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-1-(isonicotinoyl) pyrazoles

• Published in: International journal of antimicrobial agents Vol. 32; no. 2; pp. 139 - 144
• Main Authors: Almeida da Silva, Pedro E, Ramos, Daniela F, Bonacorso, Helio G, de la Iglesia, Agustina I, Oliveira, Marli R, Coelho, Tatiane, Navarini, Jussara, Morbidoni, Hector R, Zanatta, Nilo, Martins, Marcos A P
• Format: Journal Article
• Language: English
• Published: Netherlands 01.08.2008
• Subjects: Antitubercular Agents - chemical synthesis; Antitubercular Agents - pharmacology; Drug Resistance, Bacterial; Humans; Isoniazid - chemistry; Isoniazid - pharmacology; Microbial Sensitivity Tests; Mycobacterium - drug effects; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Pyrazoles - chemical synthesis; Pyrazoles - pharmacology

A series of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-1H-1-isonicotinoyl-4,5-dihydropyrazoles (2a-i) were synthesised by the cyclocondensation reaction of 4-methoxy-1,1,1-trifluoro[chloro]-4-(substituted)-alk-3-en-2-ones (1a-i) and isoniazid (INH). Their in vitro antimicrobial activity was t...