Circadian clock gene expression regulates cancer cell growth through glutaminase

• Published in: Acta biochimica et biophysica Sinica Vol. 46; no. 5; pp. 409 - 414
• Main Authors: Huang, Aixia, Bao, Bingbo, Gaskins, H Rex, Liu, Haijun, Zhang, Xueli, Lu, Liwen, Gao, Shan, Shi, Yihai, Zhang, Ming, Shan, Yuanzhou, Feng, Jing, Yao, Guoxiang
• Format: Journal Article
• Language: English
• Published: China Oxford University Press 01.05.2014
• Subjects: Animals; Base Sequence; Cell Division; Circadian Clocks - genetics; DNA Primers; Gene Expression Regulation, Neoplastic; Glutaminase - genetics; Glutaminase - metabolism; Male; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; 基因表达; 恶性肿瘤细胞; 昼夜节律钟; 生物钟基因; 细胞生长; 聚合酶链反应; 肝癌; 谷氨酰胺酶; glutaminase; circadian clock gene; cancer

Glutamine is an essential amino acid for malignant tumor cells. Glutaminase that metabolizes glutamine reaches a maximum expression in tumors immediately before the maximum proliferation rate. Tumor cells grow at different rates during the day. We postulated that the activity of glutaminase in tumor...