Clinical and neuroimaging markers of neurodegeneration in first-degree relatives of patients with REM sleep behavior disorder with and without isolated rapid eye movement sleep without atonia: A case-control clinical and dopamine PET study

• Published in: Parkinsonism & related disorders Vol. 107; p. 105271
• Main Authors: Chau, Steven Wai Ho, Liu, Yaping, Zhang, Jihui, Leung, Eric, Chen, Sirong, Ho, Chi Lai, Chan, Joey Wing Yan, Tsang, Chi Ching, Li, Shirley X., Huang, Bei, Lam, Siu Ping, Mok, Vincent CT, Wing, Yun Kwok
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2023
• Subjects: Case-Control Studies; Cross-Sectional Studies; Dementia; Dopamine; Follow-Up Studies; Humans; Muscle Hypotonia; Parkinson Disease - diagnostic imaging; Parkinson Disease - genetics; Polysomnography - methods; Positron Emission Tomography Computed Tomography; REM Sleep Behavior Disorder - diagnostic imaging; Sleep, REM; PD; RBD; vPSG; DLB; RSWA; EMG; FDRs

The current study aimed to examine the neurodegenerative implication of isolated REM sleep without atonia (RSWA) among first-degree relatives of patients with REM sleep behaviour disorder (RBD). This cross-sectional case-control study recruited three groups of subjects: First-degree relatives of RBD...