SLAMF9 aggravates myocardial ischemia reperfusion injury through activating the hippo-yap pathway

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 8; p. 130821
• Main Authors: Liu, Tingting, Guo, Xiuli, Fu, Yanhua, Zhang, Weili
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2025
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; agglutinins; Animals; Apoptosis; cardiomyocytes; Cell Line; echocardiography; family; fibrosis; Hippo Signaling Pathway; Hippo-yap pathway; hypertrophy; inflammation; Inflammatory response; lymphocyte proliferation; macrophages; Macrophages - metabolism; Male; Myocardial infarction; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Myocardial Reperfusion Injury - genetics; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Protein Serine-Threonine Kinases - metabolism; Rats; Rats, Sprague-Dawley; reperfusion injury; secretion; Signal Transduction; Signaling Lymphocytic Activation Molecule Family - genetics; Signaling Lymphocytic Activation Molecule Family - metabolism; SLAMF9; viability; Western blotting; wheat germ; YAP-Signaling Proteins - metabolism; Myocardial infarction; Inflammatory response; Hippo-yap pathway; SLAMF9; Apoptosis

The objective was to investigate the impact of signaling lymphocyte activation molecule family member 9 (SLAMF9) on myocardial infarction (MI) and its mechanisms. SLAMF9 expression in MI rats was firstly measured. SLAMF9 effect on cardiac functions, myocardial fibrosis, cardiomyocyte hypertrophy, ca...