MYO1E, Focal Segmental Glomerulosclerosis, and the Cytoskeleton
Focal segmental glomerulosclerosis, one of the most common glomerulopathies, is typically heralded by massive proteinuria, often associated with unremitting nephrotic syndrome and inexorable progression to end-stage kidney disease. 1 – 3 Unfortunately, therapy is frequently unsuccessful — many patie...
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| Published in | The New England journal of medicine Vol. 365; no. 4; pp. 368 - 369 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
Massachusetts Medical Society
28.07.2011
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Focal segmental glomerulosclerosis, one of the most common glomerulopathies, is typically heralded by massive proteinuria, often associated with unremitting nephrotic syndrome and inexorable progression to end-stage kidney disease.
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Unfortunately, therapy is frequently unsuccessful — many patients with this disorder do not respond to treatment with glucocorticoids, and immunosuppressive therapy often fails as well. The disease also frequently recurs after kidney transplantation.
The podocyte is critical to the development of focal segmental glomerulosclerosis. This dynamic cell controls glomerular filtration by means of its slit-pore diaphragm and other properties, which include motility along the glomerular basement membrane.
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Podocytes surround and adhere . . . |
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| AbstractList | Focal segmental glomerulosclerosis, one of the most common glomerulopathies, is typically heralded by massive proteinuria, often associated with unremitting nephrotic syndrome and inexorable progression to end-stage kidney disease.
1
–
3
Unfortunately, therapy is frequently unsuccessful — many patients with this disorder do not respond to treatment with glucocorticoids, and immunosuppressive therapy often fails as well. The disease also frequently recurs after kidney transplantation.
The podocyte is critical to the development of focal segmental glomerulosclerosis. This dynamic cell controls glomerular filtration by means of its slit-pore diaphragm and other properties, which include motility along the glomerular basement membrane.
4
Podocytes surround and adhere . . . Focal segmental glomerulosclerosis, one of the most common glomerulopathies, is typically heralded by massive proteinuria, often associated with unremitting nephrotic syndrome and inexorable progression to end-stage kidney disease.1–3 Unfortunately, therapy is frequently unsuccessful — many patients with this disorder do not respond to treatment with glucocorticoids, and immunosuppressive therapy often fails as well. The disease also frequently recurs after kidney transplantation. The podocyte is critical to the development of focal segmental glomerulosclerosis. This dynamic cell controls glomerular filtration by means of its slit-pore diaphragm and other properties, which include motility along the glomerular basement membrane.4 Podocytes surround and adhere . . . |
| Author | Ingelfinger, Julie R |
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| Cites_doi | 10.1056/NEJMoa1101273 10.1007/s00467-010-1692-x 10.1038/nm.1857 10.1111/j.1523-1755.2005.00723.x 10.1093/ndt/gfq617 10.1053/j.ajkd.2003.10.024 10.1093/ndt/gfg1045 10.1126/scitranslmed.3002231 10.1007/s00431-009-1017-x |
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| SubjectTerms | Calcineurin Inhibitors Cyclosporine - pharmacology Cyclosporine - therapeutic use Cytoskeleton Cytoskeleton - drug effects Diaphragm Disease Drug Resistance End-stage renal disease Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Genes Glomerulosclerosis, Focal Segmental - drug therapy Glomerulosclerosis, Focal Segmental - genetics Glucocorticoids Glucocorticoids - pharmacology Glucocorticoids - therapeutic use Humans Immunosuppressive agents Kidney diseases Kidney transplantation Motility Mutation Myosin Type I - genetics Nephrotic syndrome Podocytes - drug effects Podocytes - ultrastructure Proteins Proteinuria |
| Title | MYO1E, Focal Segmental Glomerulosclerosis, and the Cytoskeleton |
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