Integration of LC–MS-based untargeted and targeted metabolomics to uncover novel whole-grain wheat dietary intake biomarkers in the plasma of the Chinese population

• Published in: Food research international Vol. 202; p. 115740
• Main Authors: Yang, Yunjia, Zhou, Yalin, Ye, Wanyun, Shi, Hanxu, Wen, Zhang, Peng, Yile, Han, Muke, Shao, Bing, Xu, Yajun
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.02.2025
• Subjects: Adult; Asian People; Biomarker; biomarkers; Biomarkers - blood; China; Chromatography, Liquid - methods; clinical trials; compliance; Cross-Over Studies; Diet; dose response; East Asian People; Female; food intake; food research; Humans; ingestion; Liquid Chromatography-Mass Spectrometry; Male; metabolism; metabolites; Metabolomics; Metabolomics - methods; Middle Aged; nutritional intervention; oxidation; Phytochemical; quantitative analysis; refined grains; Resorcinols - blood; sulfates; Tandem Mass Spectrometry - methods; Triticum - metabolism; wheat; whole grain foods; Whole grains; Whole Grains - metabolism; Young Adult; China; Metabolomics; Biomarker; Whole grains; Phytochemical
• ISSN: 0963-9969; 1873-7145; 1873-7145
• DOI: 10.1016/j.foodres.2025.115740

[Display omitted] •The first dietary intervention study to identify WG BFIs in the Chinese population.•AR-OOH-sul were firstly identified as novel short-term WG Plasma BFIs.•AR-glu is considered a promising medium- and long-term WG BFIs.•Predictive ability and dose–response of BFIs was validated in...