Effect of cholinergic agonists on bulbospinal C1 neurons in rats

• Published in: The American journal of physiology Vol. 272; no. 1 Pt 2; p. R249
• Main Authors: Huangfu, D, Schreihofer, M, Guyenet, P G
• Format: Journal Article
• Language: English
• Published: United States 01.01.1997
• Subjects: Animals; Carbachol - pharmacology; Cholinergic Agonists - pharmacology; Electrophysiology; In Vitro Techniques; Male; Medulla Oblongata - cytology; Medulla Oblongata - drug effects; Medulla Oblongata - physiology; Muscarine - pharmacology; Neurons - drug effects; Neurons - physiology; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Tetrodotoxin - pharmacology; Vasomotor System - cytology; Vasomotor System - drug effects

Cholinergic inputs to the rostral ventrolateral medulla (RVLM) may contribute to sympathetic tone generation. The present study analyzes the response of RVLM neurons to cholinergic agonists. In chloralose-anesthetized rats iontophoresis of carbachol excited RVLM sympathoexcitatory neurons (+69% from...