Oxidation of nucleic acids: Chemistry of pyrene quinone (PQ 1) and development of dihydrodioxins (DHD 2) as DNA photooxidizing agents

• Published in: Journal of photochemistry and photobiology. A, Chemistry. Vol. 376; pp. 224 - 237
• Main Authors: Alsulami, Rabah N., Sallans, Larry, Khisamutdinov, Emil F., Pandey, U., Glusac, Ksenija, Wilson, R. Marshall
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01.05.2019; Elsevier BV
• Subjects: Absorption spectroscopy; Acetonitrile; Adducts; Adenine; Aromatic hydrocarbons; Atmospheric chemistry; Atomic force microscopy; Base pairs; Base stacking; Carcinogenicity; Carcinogens; Crosslinking; Cytotoxicity; Deoxyribonucleic acid; Dihydrodioxin photochemistry; Diketones; DNA; DNA adducts; DNA atomic force microscopy; DNA damage; DNA mass spectrometry; DNA Photochemistry; Electrochemistry; Electron transfer; Electrons; Epoxides; Free energy; Gene sequencing; Gibbs free energy; Hydrogen bonding; Hydrogen bonds; Intermediates; Ionization; Mass spectroscopy; Metabolic activation; Metabolic rate; Nucleic acids; Nucleotide sequence; Nucleotides; Organic chemistry; Ortho-quinone photochemistry; Oxidation; Photochemicals; Plasmids; Polycyclic aromatic hydrocarbons; Pyrene; Quinones; Sperm; Stilbene; DNA atomic force microscopy; Ortho-quinone photochemistry; DNA Photochemistry; Dihydrodioxin photochemistry; DNA mass spectrometry

[Display omitted] •Pyrene quinone photochemistry.•Dipyridinium dihydrodioxin photochemistry.•Photochemical damage to DNA.•Mass spectrometry of DNA damage.•Atomic force microscopy of DNA damage. Pyrene-4,5-dione (pyrene quinone, PQ 1) is a polycyclic aromatic hydrocarbon (PAH), a planar group and DNA...