Helicobacter pylori delays neutrophil apoptosis but also drives the formation of cells with a leaky plasma membrane: Implications for inflammation

• Published in: Molecular immunology Vol. 183; pp. 236 - 245
• Main Authors: Thai, Tran Duong, Kamsom, Chatcharin, Phoksawat, Wisitsak, Nithichanon, Arnone, Faksri, Kiatichai, Sripa, Banchob, Edwards, Steven W., Salao, Kanin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2025
• Subjects: Antigens, Bacterial - immunology; Apoptosis; Apoptosis - immunology; Bacterial Proteins - immunology; basins; cagA; Cell Membrane - immunology; Cell Membrane - metabolism; Cell Membrane - microbiology; Cell Membrane - pathology; cell viability; coculture; Coculture Techniques; Helicobacter Infections - immunology; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori - immunology; Humans; inflammation; Inflammation - immunology; Inflammation - microbiology; Inflammation - pathology; longevity; mixed infection; Neutrophil Activation - immunology; Neutrophils; Neutrophils - immunology; Neutrophils - microbiology; Neutrophils - pathology; Opisthorchis viverrini; pathogenicity; phagocytosis; Phagocytosis - immunology; plasma membrane; propidium; public health; reactive oxygen species; Reactive Oxygen Species - metabolism; Helicobacter pylori; Opisthorchis viverrini; cagA; Neutrophils; Apoptosis

Opisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) is a significant public health concern in countries in the Lower Mekong Basin. OV is a reservoir for Helicobacter pylori (H. pylori), and so many individuals are co-infected with these two biological carcinogens. Our study aimed to investi...