Substrate Recognition by Retroviral Integrases

• Published in: Advances in Virus Research Vol. 52; pp. 371 - 395
• Main Authors: Katzman, Michael, Katz, Richard A.
• Format: Book Chapter Journal Article
• Language: English
• Published: United States Elsevier Science & Technology 1999
• Subjects: AIDS/HIV; Animals; DNA - metabolism; DNA, Viral - metabolism; HIV Integrase - metabolism; Humans; Integrases - metabolism; Retroviridae - enzymology; Retrovirus; Substrate Specificity

This chapter focuses on the in vitro and in vivo data that have shaped the understanding of how retroviral Integrases (INs) recognize the viral and host DNA substrates. These studies have contributed to the current models of integration and could lead to the development of specific inhibitors that t...