Calcium release by cholecystokinin analogue OPE is IP3 dependent in single rat pancreatic acinar cells

• Published in: The American journal of physiology Vol. 267; no. 1 Pt 1; p. C220
• Main Authors: Gaisano, H Y, Wong, D, Sheu, L, Foskett, J K
• Format: Journal Article
• Language: English
• Published: United States 01.07.1994
• Subjects: Animals; Calcium - metabolism; Carbachol - pharmacology; Cell Separation; Cholecystokinin - analogs & derivatives; Cholecystokinin - pharmacology; Inositol 1,4,5-Trisphosphate - pharmacology; Intracellular Membranes - metabolism; Male; Microinjections; Osmolar Concentration; Pancreas - cytology; Pancreas - metabolism; Peptide Fragments - pharmacology; Rats; Rats, Sprague-Dawley; Signal Transduction; Sincalide - analogs & derivatives; Sincalide - pharmacology

Cholecystokinin (CCK) and carbachol raise intracellular Ca2+ concentration ([Ca2+]i) in pancreatic acinar cells by elevating inositol 1,4,5-trisphosphate (IP3). CCK analogues JMV-180 and OPE stimulate fully efficacious enzyme secretion and [Ca2+]i oscillations but release Ca2+ from intracellular sto...