Enhanced responding for conditioned reward produced by intra-accumbens amphetamine is potentiated after cocaine sensitization

• Published in: Psychopharmacologia Vol. 142; no. 1; pp. 31 - 40
• Main Authors: Taylor, J. R., Horger, B. A.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.02.1999; Springer Nature B.V
• Subjects: Amphetamine - pharmacology; Amphetamines; Animals; Biological and medical sciences; Cocaine; Cocaine - pharmacology; Conditioned reinforcement; Conditioned stimulus; Conditioning (Psychology) - drug effects; Dopamine Agents - pharmacology; Dopamine Uptake Inhibitors - pharmacology; Drug abuse; Drug addictions; Drug Synergism; Male; Medical sciences; Mesolimbic system; Motor Activity - drug effects; Nucleus accumbens; Nucleus Accumbens - drug effects; Nucleus Accumbens - physiology; Psychomotor stimulants; Rats; Rats, Sprague-Dawley; Reward; Stimulants; Toxicology; Amphetamine derivatives; Intraperitoneal administration; Positive reinforcement; Rat; CNS stimulant; Psychotropic; Rodentia; Central nervous system; Instrumental conditioning; Basal ganglion; Nucleus accumbens; Locomotion; Vertebrata; Mammalia; Acquisition process; Preexposure; Animal; Intracerebral administration; Cocaine; Dexamfetamine; Drug of abuse; Mechanism of action; Brain (vertebrata)

The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary r...