Hemodilution, central blood volume, and renal responses after an isotonic saline infusion in humans

• Published in: The American journal of physiology Vol. 272; no. 2 Pt 2; p. R549
• Main Authors: Johansen, L B, Bie, P, Warberg, J, Christensen, N J, Hammerum, M, Videbaek, R, Norsk, P
• Format: Journal Article
• Language: English
• Published: United States 01.02.1997
• Subjects: Adult; Blood Volume - drug effects; Cardiovascular System - drug effects; Electrolytes - blood; Endocrine Glands - drug effects; Hematocrit; Hemodilution; Hemoglobins - analysis; Humans; Isotonic Solutions; Kidney - drug effects; Kidney - physiology; Male; Plasma - metabolism; Plasma Volume; Renin - blood; Sodium Chloride - pharmacology

To test the hypothesis that hemodilution is a mediator of the renal responses to an isotonic saline infusion in the supine position, eight males underwent 1) intravenous infusion of 1.5 liter of saline over 21 min (Saline), 2) infusion of 1.5 liter of saline in combination with lower body negative p...