Mirtazapine for obsessive-compulsive disorder: an open trial followed by double-blind discontinuation

• Published in: The journal of clinical psychiatry Vol. 66; no. 4; p. 515
• Main Authors: Koran, Lorrin M, Gamel, Nona N, Choung, Helen W, Smith, Emily H, Aboujaoude, Elias N
• Format: Journal Article
• Language: English
• Published: United States 01.04.2005
• Subjects: Adult; Antidepressive Agents, Tricyclic - therapeutic use; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Mianserin - analogs & derivatives; Mianserin - therapeutic use; Obsessive-Compulsive Disorder - diagnosis; Obsessive-Compulsive Disorder - drug therapy; Obsessive-Compulsive Disorder - psychology; Pilot Projects; Psychiatric Status Rating Scales; Treatment Outcome

Many patients with obsessive-compulsive disorder (OCD) experience little response to standard treatment with serotonin reuptake inhibitors. Mirtazapine enhances serotonergic function by a mechanism distinct from reuptake inhibition. Because a pilot study suggested effectiveness of mirtazapine in OCD...