Comparison of resmetirom quantative analysis in API and formulation models based on PXRD, FTIR and Raman scanning imaging combined with univariate and multivariate analyses

• Published in: Talanta (Oxford) Vol. 287; p. 127568
• Main Authors: Yang, Chen, Luo, Ying, Sun, Wenxia, Liu, Xiangkui, Zhu, Xueyan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.05.2025
• Subjects: bioavailability; drugs; fatty liver; FTIR; humidity; Least-Squares Analysis; Multivariate Analysis; Polymorphism; PXRD; Quantitative; quantitative analysis; Raman; Resmetirom; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Tablets; temperature; X-Ray Diffraction; Resmetirom; Raman; Quantitative; FTIR; Polymorphism; PXRD

Resmetirom is the first innovative drug for the treatment of non-alcoholic steatohepatitis (NASH), and its two crystal forms, form I and form-2H2O, were mentioned in the original patent. The commercially available crystal form of resmetirom was form I. However, the tablets were subject to temperatur...