Preparation and structural characterization of a sulfated octasaccharide with heparin-like anticoagulant activity

Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus residues. Patients using heparin also face the risks of spontaneous bleeding and thrombocytopenia. Here we reported an efficient riclinoctaose-ba...

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Published inCarbohydrate polymers Vol. 347; p. 122782
Main Authors Yu, Ning, Fang, Rui, Ding, Zhao, Xu, Xi, Zhang, Jianfa
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.01.2025
Subjects
animal viruses
Animals
anticoagulant activity
Anticoagulant effect
anticoagulants
Anticoagulants - chemistry
Anticoagulants - pharmacology
blood
Blood Coagulation - drug effects
coagulation
Fourier transform infrared spectroscopy
heparin
Heparin - chemistry
Heparin - pharmacology
Humans
Male
Mice
molecular weight
Oligosaccharides - chemical synthesis
Oligosaccharides - chemistry
Oligosaccharides - pharmacology
Riclinoctaose
risk
Sulfated oligosaccharide
Sulfates - chemistry
sulfur
Sulfur trioxide-trimethylamine complexes
synthesis
thrombocytopenia
thrombosis
Thrombosis - chemically induced
Thrombosis - drug therapy
Thrombosis - prevention & control
Riclinoctaose
Anticoagulant effect
Sulfur trioxide-trimethylamine complexes
Sulfated oligosaccharide
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Abstract Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus residues. Patients using heparin also face the risks of spontaneous bleeding and thrombocytopenia. Here we reported an efficient riclinoctaose-based approach for rapid chemical synthesis of a structurally defined heparin-like anticoagulant sulfated octasaccharide (SRO). We used sulfur trioxide-pyridine, sulfur trioxide-trimethylamine, and sulfur trioxide-triethylamine complexes as solvents for one-pot O-sulfation and determined the optimal conditions for synthesizing SRO. Sulfur trioxide-trimethylamine provided reasonable control over the degree of substitution between 1.85 and 1.88, revealing a single molecule with a theoretical molecular weight of 2952.96 g/mol. The structural features of the SRO were carried out by Fourier transform infrared spectroscopy and one- and two- dimensional 1H and 13C NMR analysis, revealing sulfation repeatedly present at the fixed positions of C-6/C-2/C-3 and reducing terminals. The anticoagulant activity of SRO was demonstrated by efficiently blocking coagulation in the blood of mice and human. SRO dose-dependently decreased ferric chloride-induced experimental thrombosis in mice. Like heparin, SRO specifically inhibits coagulation factor Xa, but significantly reduces the risk of bleeding compared to heparin. Therefore, we named it octaparin. These results support that octaparin is expected to replace animal-sourced heparin. [Display omitted]
AbstractList Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus residues. Patients using heparin also face the risks of spontaneous bleeding and thrombocytopenia. Here we reported an efficient riclinoctaose-based approach for rapid chemical synthesis of a structurally defined heparin-like anticoagulant sulfated octasaccharide (SRO). We used sulfur trioxide-pyridine, sulfur trioxide-trimethylamine, and sulfur trioxide-triethylamine complexes as solvents for one-pot O-sulfation and determined the optimal conditions for synthesizing SRO. Sulfur trioxide-trimethylamine provided reasonable control over the degree of substitution between 1.85 and 1.88, revealing a single molecule with a theoretical molecular weight of 2952.96 g/mol. The structural features of the SRO were carried out by Fourier transform infrared spectroscopy and one- and two- dimensional 1H and 13C NMR analysis, revealing sulfation repeatedly present at the fixed positions of C-6/C-2/C-3 and reducing terminals. The anticoagulant activity of SRO was demonstrated by efficiently blocking coagulation in the blood of mice and human. SRO dose-dependently decreased ferric chloride-induced experimental thrombosis in mice. Like heparin, SRO specifically inhibits coagulation factor Xa, but significantly reduces the risk of bleeding compared to heparin. Therefore, we named it octaparin. These results support that octaparin is expected to replace animal-sourced heparin. [Display omitted]
Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus residues. Patients using heparin also face the risks of spontaneous bleeding and thrombocytopenia. Here we reported an efficient riclinoctaose-based approach for rapid chemical synthesis of a structurally defined heparin-like anticoagulant sulfated octasaccharide (SRO). We used sulfur trioxide-pyridine, sulfur trioxide-trimethylamine, and sulfur trioxide-triethylamine complexes as solvents for one-pot O-sulfation and determined the optimal conditions for synthesizing SRO. Sulfur trioxide-trimethylamine provided reasonable control over the degree of substitution between 1.85 and 1.88, revealing a single molecule with a theoretical molecular weight of 2952.96 g/mol. The structural features of the SRO were carried out by Fourier transform infrared spectroscopy and one- and two- dimensional 1H and 13C NMR analysis, revealing sulfation repeatedly present at the fixed positions of C-6/C-2/C-3 and reducing terminals. The anticoagulant activity of SRO was demonstrated by efficiently blocking coagulation in the blood of mice and human. SRO dose-dependently decreased ferric chloride-induced experimental thrombosis in mice. Like heparin, SRO specifically inhibits coagulation factor Xa, but significantly reduces the risk of bleeding compared to heparin. Therefore, we named it octaparin. These results support that octaparin is expected to replace animal-sourced heparin.Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus residues. Patients using heparin also face the risks of spontaneous bleeding and thrombocytopenia. Here we reported an efficient riclinoctaose-based approach for rapid chemical synthesis of a structurally defined heparin-like anticoagulant sulfated octasaccharide (SRO). We used sulfur trioxide-pyridine, sulfur trioxide-trimethylamine, and sulfur trioxide-triethylamine complexes as solvents for one-pot O-sulfation and determined the optimal conditions for synthesizing SRO. Sulfur trioxide-trimethylamine provided reasonable control over the degree of substitution between 1.85 and 1.88, revealing a single molecule with a theoretical molecular weight of 2952.96 g/mol. The structural features of the SRO were carried out by Fourier transform infrared spectroscopy and one- and two- dimensional 1H and 13C NMR analysis, revealing sulfation repeatedly present at the fixed positions of C-6/C-2/C-3 and reducing terminals. The anticoagulant activity of SRO was demonstrated by efficiently blocking coagulation in the blood of mice and human. SRO dose-dependently decreased ferric chloride-induced experimental thrombosis in mice. Like heparin, SRO specifically inhibits coagulation factor Xa, but significantly reduces the risk of bleeding compared to heparin. Therefore, we named it octaparin. These results support that octaparin is expected to replace animal-sourced heparin.
Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus residues. Patients using heparin also face the risks of spontaneous bleeding and thrombocytopenia. Here we reported an efficient riclinoctaose-based approach for rapid chemical synthesis of a structurally defined heparin-like anticoagulant sulfated octasaccharide (SRO). We used sulfur trioxide-pyridine, sulfur trioxide-trimethylamine, and sulfur trioxide-triethylamine complexes as solvents for one-pot O-sulfation and determined the optimal conditions for synthesizing SRO. Sulfur trioxide-trimethylamine provided reasonable control over the degree of substitution between 1.85 and 1.88, revealing a single molecule with a theoretical molecular weight of 2952.96 g/mol. The structural features of the SRO were carried out by Fourier transform infrared spectroscopy and one- and two- dimensional H and C NMR analysis, revealing sulfation repeatedly present at the fixed positions of C-6/C-2/C-3 and reducing terminals. The anticoagulant activity of SRO was demonstrated by efficiently blocking coagulation in the blood of mice and human. SRO dose-dependently decreased ferric chloride-induced experimental thrombosis in mice. Like heparin, SRO specifically inhibits coagulation factor Xa, but significantly reduces the risk of bleeding compared to heparin. Therefore, we named it octaparin. These results support that octaparin is expected to replace animal-sourced heparin.
Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus residues. Patients using heparin also face the risks of spontaneous bleeding and thrombocytopenia. Here we reported an efficient riclinoctaose-based approach for rapid chemical synthesis of a structurally defined heparin-like anticoagulant sulfated octasaccharide (SRO). We used sulfur trioxide-pyridine, sulfur trioxide-trimethylamine, and sulfur trioxide-triethylamine complexes as solvents for one-pot O-sulfation and determined the optimal conditions for synthesizing SRO. Sulfur trioxide-trimethylamine provided reasonable control over the degree of substitution between 1.85 and 1.88, revealing a single molecule with a theoretical molecular weight of 2952.96 g/mol. The structural features of the SRO were carried out by Fourier transform infrared spectroscopy and one- and two- dimensional ¹H and ¹³C NMR analysis, revealing sulfation repeatedly present at the fixed positions of C-6/C-2/C-3 and reducing terminals. The anticoagulant activity of SRO was demonstrated by efficiently blocking coagulation in the blood of mice and human. SRO dose-dependently decreased ferric chloride-induced experimental thrombosis in mice. Like heparin, SRO specifically inhibits coagulation factor Xa, but significantly reduces the risk of bleeding compared to heparin. Therefore, we named it octaparin. These results support that octaparin is expected to replace animal-sourced heparin.
ArticleNumber 122782
Author Yu, Ning
Fang, Rui
Xu, Xi
Zhang, Jianfa
Ding, Zhao
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  surname: Yu
  fullname: Yu, Ning
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  surname: Fang
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  givenname: Zhao
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  surname: Zhang
  fullname: Zhang, Jianfa
  email: jfzhang@mail.njust.edu.cn
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Cites_doi 10.4103/0972-5229.76083
10.1007/s12272-016-0708-x
10.1053/j.semtcvs.2018.10.011
10.1182/blood-2005-07-3043
10.1016/j.carbpol.2022.120370
10.1016/j.carbpol.2006.03.011
10.1016/j.ijbiomac.2024.129591
10.1007/s11483-012-9279-7
10.1016/j.carbpol.2024.122317
10.1038/202498a0
10.1016/j.carres.2012.08.020
10.1381/096089203764467153
10.1016/j.drudis.2020.09.011
10.1016/j.ijbiomac.2019.11.124
10.1016/j.ijbiomac.2013.04.005
10.1007/s11239-011-0551-3
10.1016/j.thromres.2005.07.020
10.1182/blood-2017-05-785253
10.1046/j.1538-7836.2003.00270.x
10.1021/acsnano.0c09939
10.1016/j.ejmech.2022.114256
10.1016/j.ijbiomac.2019.04.077
10.1016/S1872-2040(15)60835-0
10.1055/s-0040-1715460
10.1021/acs.jafc.0c07783
10.1016/j.foodhyd.2011.02.009
10.1016/j.jmbbm.2021.104851
10.1007/s00289-020-03344-8
10.1002/anie.201404154
10.1021/acs.joc.8b02792
10.1126/scitranslmed.aan5954
10.1016/j.carbpol.2007.06.026
10.1016/j.ijbiomac.2019.06.122
10.1038/s41467-020-16924-z
10.1016/S0008-6215(01)00066-0
10.1039/D0SC03922E
10.1016/S0140-6736(22)02128-6
10.1160/th15-07-0598
10.3390/molecules20035085
10.1007/s00018-022-04257-7
10.1056/NEJMoa0806450
10.1016/j.blre.2019.100615
10.1182/blood-2007-10-120543
10.1111/jth.12249
10.1002/cmdc.201400019
10.1016/S0021-9150(96)05980-1
10.1111/jth.15606
10.1016/j.carbpol.2017.07.009
10.1016/j.tifs.2023.104317
10.1016/S0140-6736(11)60876-3
10.1213/ANE.0b013e31827e4e62
10.1182/bloodadvances.2018016337
10.1021/acs.biomac.0c00654
10.4244/EIJ-D-22-00432
10.1021/acsami.4c01088
10.1111/jth.13312
10.1016/j.surg.2018.05.028
10.1038/s41422-019-0260-6
10.1136/pgmj.2007.059188
10.1016/j.carbpol.2021.119054
10.1111/j.1538-7836.2011.04321.x
10.1517/14656566.2011.570261
10.1378/chest.11-2291
10.1172/JCI27196
10.1016/j.ijbiomac.2011.09.024
10.1016/j.carbpol.2022.119829
10.1002/adma.202200549
10.1177/10742484221145010
10.3390/agronomy13123078
10.1021/bm049693s
10.1126/sciadv.abd0130
10.3390/bioengineering9120765
10.1002/ange.201908805
10.1016/j.colsurfb.2022.112359
10.1126/sciadv.abf9635
10.3892/etm.2013.1277
10.1155/2019/9545297
10.4103/0019-5049.144643
10.1515/cclm-2013-0278
10.1016/j.carbpol.2012.07.077
10.5811/westjem.2014.12.22933
10.1016/j.carbpol.2016.06.106
10.1007/s00253-018-9263-3
10.1007/s11239-009-0376-5
10.1016/0002-9378(95)90443-3
10.1161/ATVBAHA.115.305996
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Keywords Riclinoctaose
Anticoagulant effect
Sulfur trioxide-trimethylamine complexes
Sulfated oligosaccharide
Language English
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References Ding, Vara Prasad, Wang (bb0120) 2019; 2019
Macfarlane (bb0275) 1964; 202
Sheehan, Walke (bb0360) 2006; 107
Bertini, Bisio, Torri, Bensi, Terbojevich (bb0030) 2005; 6
Li, Zhao, Feng, Dou, Ding, Zhou, Lu, Zhang, Chen, Li, Li, Zhao, Jiang, Wang, Zhao, Cheng, Zhang (bb0245) 2020; 11
Maciel, Chaves, Souza, Teixeira, Freitas, Feitosa, de Paula (bb0280) 2008; 71
Haselbach, Maurer, Vogel, Harder, Weber, Baykut, Mäntele (bb0195) 2013; 51
Li, Ye, Cao, Wang, Liu, Zhou, Liu, Wang, Shen, Zhao, Wang (bb0250) 2014; 9
Han, Xing, Yu, Zeng, Zhang (bb0185) 2015; 43
Tang, Zhang, Fang, Han, Wang, Wang, Xue, Li, Zhang, Wu, Yang, Mwangi, Lu, Du, Lai (bb0385) 2020; 30
Gorelik, Lin, Briceno-Strocchia, Taylor (bb0170) 2019; 84
Gómez-Ordóñez, Rupérez (bb0160) 2011; 25
Beurskens, Huckriede, Schrijver, Hemker, Reutelingsperger, Nicolaes (bb0035) 2020; 120
Finley, Greenberg (bb0145) 2013; 116
Zhou, Zhang, Wu, Luo, Wu, Xu, Wu (bb0430) 2022; 234
Rausa, Kelly, Asti, Aiolfi, Bonitta, Winter, Bonavina (bb0350) 2018; 164
Solanki, Shenoy, Downs, Palkimas, Goldman, Sharma (bb0375) 2019; 31
Yeh, Yu, Vappala, Kalathottukaren, Abbina, Luo, Kizhakkedathu (bb0410) 2021; 124
Fan, Wu, Zhang, Gao, Wang, Li, Sha, Xie, Nie (bb0135) 2012; 50
He, Adili, Liu, Hong, Holinstat, Schwendeman (bb0200) 2020; 6
Ahmed, Majeed, Powell (bb0005) 2007; 83
Bolten, Rinas, Scheper (bb0065) 2018; 102
Bi, Huang, Cao, Yao, Guo, Zhang, Wu, Xu, Hu, Xu (bb0040) 2023; 301
Bauersachs (bb0020) 2023; 28
Huynh, Chaubet, Jozefonvicz (bb0215) 2001; 332
Huang, Zhao, Shui, Guo, Wang (bb0210) 2020; 11
González-Espinosa, Sabagh, Moldenhauer, Clarke, Goycoolea (bb0165) 2019; 136
Iqbal, Cohen (bb0220) 2011; 12
Lu, Wang, Kong, Chen, Hu, Zhang (bb0270) 2024; 16
Chen, Shen, Yu, Chen, Xie (bb0080) 2024; 144
Barbour, Smith, Marlar (bb0010) 1995; 173
Harter, Levine, Henderson (bb0190) 2015; 16
Ku, Yoon, Lee, Kwon, Lee, Bae (bb0235) 2016; 39
Montalescot, Zeymer, Silvain, Boulanger, Cohen, Goldstein, Vicaut (bb0300) 2011; 378
Sikka, Bindra (bb0370) 2010; 14
Dementiev, Silva, Yee, Li, Flavin, Sham, Partridge (bb0110) 2018; 2
Gremmel, Ay, Riedl, Kopp, Eichelberger, Koppensteiner, Panzer (bb0175) 2016; 115
Rafigh, Rahimpour Soleymani, Heydarinasab (bb0345) 2021; 78
Chang, Lico, Huang, Lin, Chang, Arco, Hung (bb0075) 2014; 53
Cuker, Cines, Arepally (bb0105) 2014
Blossom, Kallen, Patel, Elward, Robinson, Gao, Sasisekharan (bb0060) 2008; 359
Crowther, Warkentin (bb0100) 2008; 111
Mast (bb0290) 2016; 36
Chong (bb0095) 2003; 1
Szymanska-Chargot, Zdunek (bb0380) 2013; 8
La, Takeuchi, Abbina, Vappala, Abbasi, Kizhakkedathu (bb0240) 2020; 21
Guo, Wang, Zhao, Li, Wang, Zhong, Mequanint, Zhan, Xing, Luo (bb0180) 2021; 7
Pang, Cui, Chen, Cheng, Delaney, Gu, Du (bb0320) 2018; 132
Liu, Hao, Shan, Zhang, Zhao, Li, Wang, Cai, Li, Yu (bb0265) 2016; 152
Chandarajoti, Liu, Pawlinski (bb0070) 2016; 14
Reyes-Weiss, Bligh, Rhein-Knudsen, Hehemann, Liebeke, Westereng, Horn (bb2350) 2024; 340
Lin, Yu, Liu, Liu, Lu, Cao, Qi, Zhou, Li, Liu, Tian, Li (bb0255) 2022; 34
Zhang, Chen, Wen, Zhou, Gu, Duan, Zhang, Ren, Ma (bb0420) 2019; 133
Ji, Ji, Meng (bb0225) 2013; 6
Cheng, Zheng, Duan, Cai, Zhang (bb0090) 2024; 261
Monfared, Mahmoudian, Hoti, Bisericaru, Caldera, Cavalli, Trotta (bb0295) 2022; 9
Yu, Shen, Wang, Wang, Xie, Xie (bb0415) 2017; 174
Shepherd, Rosborough, Schwartz (bb0365) 2003; 13
Baytas, Linhardt (bb0025) 2020; 25
Østerud, Latysheva, Schoergenhofer, Jilma, Hansen, Snir (bb0310) 2022; 20
Pawar, Wang, Higo, Bhattacharya, Kancharla, Zhang, Hsieh-Wilson (bb0325) 2019; 131
Rocha Neto, Copes, Chevallier, Vieira, da Silva, Mantovani, Beppu (bb0355) 2022; 213
Manikowski, Kozioł, Czajkowska-Wojciechowska (bb0285) 2012; 361
Lin, Zhao, Gao, Yin, Li, Sun, Zhao (bb0260) 2020; 39
Wang, Zhang, Yao, Zhao, Qi (bb0395) 2013; 58
Xu, Chandarajoti, Zhang, Pagadala, Dou, Hoppensteadt, Liu (bb0405) 2017; 9
Emilsson, Bergman, Mohammad, Olivecrona, Götberg, Erlinge, Koul (bb0125) 2022; 18
Fazavana, Bianchini, Saller, Smadja, Picard, Taverna, Borgel (bb0140) 2013; 11
Chen, Sun, Shan, Tang, Hu, Shen, Qiao, Li, Zhuang, Zhu, Ying (bb0085) 2020; 155
Gawaz, Langer, May (bb0155) 2005; 115
Qi, Mao, Gao, Chen, Chen, Zhao, Li, Wang, Yan, Lin, Shan (bb0340) 2012; 90
Zhang, Shen, Fang, Han, Long, Liu, Yang, Liu, Zhang, Cao, Chen, Fang, Lu, Hou, Li, Liu, Lei, Ni, Lai (bb0425) 2022; 79
Blann, Lip (bb0055) 1997; 128
Keating, Dauerman, Whitaker, Sobel, Schneider (bb0230) 2006; 118
Peng, Jiang, He, She, Li, Chen, Zhang, Lin, Zhang, Wang, He, Wang, Tang, Luo (bb0330) 2023; 13
Esposito, Vessella, Sinquin, Traboni, Iadonisi, Colliec-Jouault, Bedini (bb0130) 2022; 283
Wang, Cheng, Sun, Zhao, Ge, Yang, Gao, Ding, Liu, Zhang (bb0390) 2021; 69
Bistervels, Buchmüller, Wiegers, Áinle, Tardy, Donnelly, Zelis (bb0050) 2022; 400
Garcia, Baglin, Weitz, Samama (bb0150) 2012; 141
Wong, Pinto, Zhang (bb0400) 2011; 31
Bauer (bb0015) 2011; 9
Prasertsan, Dermlim, Doelle, Kennedy (bb0335) 2006; 66
Nielly, Bousquet, Le Garlantezec, Perrier, Bohand (bb0305) 2010; 29
Palta, Saroa, Palta (bb0315) 2014; 58
Hu, Wang, Hu, Yin, Wang, Du, Chen, Kang (bb0205) 2022; 295
Bisio, Mantegazza, Vecchietti, Bensi, Coppa, Torri, Bertini (bb0045) 2015; 20
Deng, Zhang, Lv, Liu, Ren, Qu (bb0115) 2021; 15
Bi (10.1016/j.carbpol.2024.122782_bb0040) 2023; 301
Bisio (10.1016/j.carbpol.2024.122782_bb0045) 2015; 20
Ku (10.1016/j.carbpol.2024.122782_bb0235) 2016; 39
Blann (10.1016/j.carbpol.2024.122782_bb0055) 1997; 128
Li (10.1016/j.carbpol.2024.122782_bb0245) 2020; 11
Maciel (10.1016/j.carbpol.2024.122782_bb0280) 2008; 71
Macfarlane (10.1016/j.carbpol.2024.122782_bb0275) 1964; 202
Chen (10.1016/j.carbpol.2024.122782_bb0080) 2024; 144
Han (10.1016/j.carbpol.2024.122782_bb0185) 2015; 43
Zhou (10.1016/j.carbpol.2024.122782_bb0430) 2022; 234
Chang (10.1016/j.carbpol.2024.122782_bb0075) 2014; 53
Fazavana (10.1016/j.carbpol.2024.122782_bb0140) 2013; 11
Pawar (10.1016/j.carbpol.2024.122782_bb0325) 2019; 131
Fan (10.1016/j.carbpol.2024.122782_bb0135) 2012; 50
Rafigh (10.1016/j.carbpol.2024.122782_bb0345) 2021; 78
Baytas (10.1016/j.carbpol.2024.122782_bb0025) 2020; 25
Beurskens (10.1016/j.carbpol.2024.122782_bb0035) 2020; 120
Palta (10.1016/j.carbpol.2024.122782_bb0315) 2014; 58
Yu (10.1016/j.carbpol.2024.122782_bb0415) 2017; 174
Zhang (10.1016/j.carbpol.2024.122782_bb0420) 2019; 133
Chong (10.1016/j.carbpol.2024.122782_bb0095) 2003; 1
Harter (10.1016/j.carbpol.2024.122782_bb0190) 2015; 16
Reyes-Weiss (10.1016/j.carbpol.2024.122782_bb2350) 2024; 340
Liu (10.1016/j.carbpol.2024.122782_bb0265) 2016; 152
Wang (10.1016/j.carbpol.2024.122782_bb0390) 2021; 69
Rausa (10.1016/j.carbpol.2024.122782_bb0350) 2018; 164
Ahmed (10.1016/j.carbpol.2024.122782_bb0005) 2007; 83
Pang (10.1016/j.carbpol.2024.122782_bb0320) 2018; 132
He (10.1016/j.carbpol.2024.122782_bb0200) 2020; 6
Monfared (10.1016/j.carbpol.2024.122782_bb0295) 2022; 9
Bauersachs (10.1016/j.carbpol.2024.122782_bb0020) 2023; 28
Bertini (10.1016/j.carbpol.2024.122782_bb0030) 2005; 6
Keating (10.1016/j.carbpol.2024.122782_bb0230) 2006; 118
Li (10.1016/j.carbpol.2024.122782_bb0250) 2014; 9
Barbour (10.1016/j.carbpol.2024.122782_bb0010) 1995; 173
La (10.1016/j.carbpol.2024.122782_bb0240) 2020; 21
Hu (10.1016/j.carbpol.2024.122782_bb0205) 2022; 295
Yeh (10.1016/j.carbpol.2024.122782_bb0410) 2021; 124
Montalescot (10.1016/j.carbpol.2024.122782_bb0300) 2011; 378
Wong (10.1016/j.carbpol.2024.122782_bb0400) 2011; 31
Lin (10.1016/j.carbpol.2024.122782_bb0255) 2022; 34
Wang (10.1016/j.carbpol.2024.122782_bb0395) 2013; 58
Qi (10.1016/j.carbpol.2024.122782_bb0340) 2012; 90
Crowther (10.1016/j.carbpol.2024.122782_bb0100) 2008; 111
Mast (10.1016/j.carbpol.2024.122782_bb0290) 2016; 36
Bolten (10.1016/j.carbpol.2024.122782_bb0065) 2018; 102
Manikowski (10.1016/j.carbpol.2024.122782_bb0285) 2012; 361
Bistervels (10.1016/j.carbpol.2024.122782_bb0050) 2022; 400
Cuker (10.1016/j.carbpol.2024.122782_bb0105) 2014
Cheng (10.1016/j.carbpol.2024.122782_bb0090) 2024; 261
Szymanska-Chargot (10.1016/j.carbpol.2024.122782_bb0380) 2013; 8
Bauer (10.1016/j.carbpol.2024.122782_bb0015) 2011; 9
Esposito (10.1016/j.carbpol.2024.122782_bb0130) 2022; 283
Garcia (10.1016/j.carbpol.2024.122782_bb0150) 2012; 141
Ding (10.1016/j.carbpol.2024.122782_bb0120) 2019; 2019
Østerud (10.1016/j.carbpol.2024.122782_bb0310) 2022; 20
Xu (10.1016/j.carbpol.2024.122782_bb0405) 2017; 9
Chandarajoti (10.1016/j.carbpol.2024.122782_bb0070) 2016; 14
Guo (10.1016/j.carbpol.2024.122782_bb0180) 2021; 7
Nielly (10.1016/j.carbpol.2024.122782_bb0305) 2010; 29
Huynh (10.1016/j.carbpol.2024.122782_bb0215) 2001; 332
Rocha Neto (10.1016/j.carbpol.2024.122782_bb0355) 2022; 213
Shepherd (10.1016/j.carbpol.2024.122782_bb0365) 2003; 13
Gawaz (10.1016/j.carbpol.2024.122782_bb0155) 2005; 115
Haselbach (10.1016/j.carbpol.2024.122782_bb0195) 2013; 51
Sikka (10.1016/j.carbpol.2024.122782_bb0370) 2010; 14
Peng (10.1016/j.carbpol.2024.122782_bb0330) 2023; 13
Chen (10.1016/j.carbpol.2024.122782_bb0085) 2020; 155
Dementiev (10.1016/j.carbpol.2024.122782_bb0110) 2018; 2
Lu (10.1016/j.carbpol.2024.122782_bb0270) 2024; 16
Blossom (10.1016/j.carbpol.2024.122782_bb0060) 2008; 359
Tang (10.1016/j.carbpol.2024.122782_bb0385) 2020; 30
Iqbal (10.1016/j.carbpol.2024.122782_bb0220) 2011; 12
Emilsson (10.1016/j.carbpol.2024.122782_bb0125) 2022; 18
Solanki (10.1016/j.carbpol.2024.122782_bb0375) 2019; 31
Ji (10.1016/j.carbpol.2024.122782_bb0225) 2013; 6
Prasertsan (10.1016/j.carbpol.2024.122782_bb0335) 2006; 66
Huang (10.1016/j.carbpol.2024.122782_bb0210) 2020; 11
Lin (10.1016/j.carbpol.2024.122782_bb0260) 2020; 39
González-Espinosa (10.1016/j.carbpol.2024.122782_bb0165) 2019; 136
Finley (10.1016/j.carbpol.2024.122782_bb0145) 2013; 116
Gorelik (10.1016/j.carbpol.2024.122782_bb0170) 2019; 84
Gremmel (10.1016/j.carbpol.2024.122782_bb0175) 2016; 115
Zhang (10.1016/j.carbpol.2024.122782_bb0425) 2022; 79
Sheehan (10.1016/j.carbpol.2024.122782_bb0360) 2006; 107
Gómez-Ordóñez (10.1016/j.carbpol.2024.122782_bb0160) 2011; 25
Deng (10.1016/j.carbpol.2024.122782_bb0115) 2021; 15
References_xml – volume: 25
  start-page: 2095
  year: 2020
  end-page: 2109
  ident: bb0025
  article-title: Advances in the preparation and synthesis of heparin and related products
  publication-title: Drug Discovery Today
– volume: 53
  start-page: 9876
  year: 2014
  end-page: 9879
  ident: bb0075
  article-title: Synthesis of the heparin-based anticoagulant drug fondaparinux
  publication-title: Angewandte Chemie International Edition
– volume: 14
  start-page: 188
  year: 2010
  end-page: 195
  ident: bb0370
  article-title: Newer antithrombotic drugs
  publication-title: Indian Journal of Critical Care Medicine: Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
– volume: 116
  start-page: 1210
  year: 2013
  end-page: 1222
  ident: bb0145
  article-title: Heparin sensitivity and resistance: Management during cardiopulmonary bypass
  publication-title: Anesthesia & Analgesia
– volume: 9
  start-page: 12
  year: 2011
  end-page: 19
  ident: bb0015
  article-title: Recent progress in anticoagulant therapy: Oral direct inhibitors of thrombin and factor Xa
  publication-title: Journal of Thrombosis and Haemostasis
– volume: 29
  start-page: 503
  year: 2010
  end-page: 511
  ident: bb0305
  article-title: Severe bleeding secondary to misuse of fondaparinux: A case report
  publication-title: Journal of Thrombosis and Thrombolysis
– volume: 20
  year: 2015
  ident: bb0045
  article-title: Determination of the molecular weight of low-molecular-weight heparins by using high-pressure size exclusion chromatography on line with a triple detector array and conventional methods
  publication-title: Molecules
– volume: 13
  start-page: 249
  year: 2003
  end-page: 253
  ident: bb0365
  article-title: Heparin thromboprophylaxis in gastric bypass surgery
  publication-title: Obesity Surgery
– volume: 51
  start-page: 2037
  year: 2013
  end-page: 2043
  ident: bb0195
  article-title: A novel method for the direct determination of heparin concentration during cardiopulmonary bypass surgery
  publication-title: Clinical Chemistry and Laboratory Medicine (CCLM)
– volume: 261
  year: 2024
  ident: bb0090
  article-title: Effect of subcritical water temperature on the structure, antioxidant activity and immune activity of polysaccharides from Glycyrrhiza inflata Batalin
  publication-title: International Journal of Biological Macromolecules
– volume: 69
  start-page: 3667
  year: 2021
  end-page: 3676
  ident: bb0390
  article-title: Preparation and gut microbiota modulatory property of the oligosaccharide riclinoctaose
  publication-title: Journal of Agricultural and Food Chemistry
– volume: 164
  start-page: 1234
  year: 2018
  end-page: 1240
  ident: bb0350
  article-title: Extended versus conventional thromboprophylaxis after major abdominal and pelvic surgery: Systematic review and meta-analysis of randomized clinical trials
  publication-title: Surgery
– volume: 9
  start-page: 765
  year: 2022
  ident: bb0295
  article-title: Hyper-branched cyclodextrin-based polymers as anticoagulant agents: In vitro and in vivo studies
  publication-title: Bioengineering
– volume: 30
  start-page: 119
  year: 2020
  end-page: 132
  ident: bb0385
  article-title: Transferrin plays a central role in coagulation balance by interacting with clotting factors
  publication-title: Cell Research
– volume: 155
  start-page: 1460
  year: 2020
  end-page: 1467
  ident: bb0085
  article-title: Flow synthesis, characterization, anticoagulant activity of xylan sulfate from sugarcane bagasse
  publication-title: International Journal of Biological Macromolecules
– volume: 152
  start-page: 343
  year: 2016
  end-page: 350
  ident: bb0265
  article-title: Antithrombotic activities of fucosylated chondroitin sulfates and their depolymerized fragments from two sea cucumbers
  publication-title: Carbohydrate Polymers
– volume: 118
  start-page: 361
  year: 2006
  end-page: 369
  ident: bb0230
  article-title: Increased expression of platelet P-selectin and formation of platelet–leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin
  publication-title: Thrombosis Research
– volume: 71
  start-page: 559
  year: 2008
  end-page: 565
  ident: bb0280
  article-title: Structural characterization of cold extracted fraction of soluble sulfated polysaccharide from red seaweed
  publication-title: Carbohydrate Polymers
– volume: 301
  year: 2023
  ident: bb0040
  article-title: Preparation, characterization and immunomodulatory effects of unsaturated sulfated oligoguluronic acid
  publication-title: Carbohydrate Polymers
– volume: 132
  start-page: 533
  year: 2018
  end-page: 543
  ident: bb0320
  article-title: Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation
  publication-title: Blood
– volume: 1
  start-page: 1471
  year: 2003
  end-page: 1478
  ident: bb0095
  article-title: Heparin-induced thrombocytopenia
  publication-title: Journal of Thrombosis and Haemostasis
– volume: 202
  start-page: 498
  year: 1964
  end-page: 499
  ident: bb0275
  article-title: An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier
  publication-title: Nature
– start-page: 511
  year: 2014
  end-page: 518
  ident: bb0105
  article-title: Chapter 60—Autoantibodies in heparin-induced thrombocytopenia
  publication-title: Autoantibodies
– volume: 15
  start-page: 6604
  year: 2021
  end-page: 6613
  ident: bb0115
  article-title: Biological mediator-propelled nanosweeper for nonpharmaceutical thrombus therapy
  publication-title: ACS Nano
– volume: 107
  start-page: 3876
  year: 2006
  end-page: 3882
  ident: bb0360
  article-title: Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism
  publication-title: Blood
– volume: 115
  start-page: 615
  year: 2016
  end-page: 621
  ident: bb0175
  article-title: Platelet-specific markers are associated with monocyte-platelet aggregate formation and thrombin generation potential in advanced atherosclerosis
  publication-title: Thrombosis and Haemostasis
– volume: 361
  start-page: 155
  year: 2012
  end-page: 161
  ident: bb0285
  article-title: An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides
  publication-title: Carbohydrate Research
– volume: 50
  start-page: 31
  year: 2012
  end-page: 37
  ident: bb0135
  article-title: Synthesis and anticoagulant activity of the quaternary ammonium chitosan sulfates
  publication-title: International Journal of Biological Macromolecules
– volume: 79
  start-page: 240
  year: 2022
  ident: bb0425
  article-title: Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
  publication-title: Cellular and Molecular Life Sciences
– volume: 173
  start-page: 1869
  year: 1995
  end-page: 1873
  ident: bb0010
  article-title: Heparin levels to guide thromboembolism prophylaxis during pregnancy
  publication-title: American Journal of Obstetrics and Gynecology
– volume: 84
  start-page: 900
  year: 2019
  end-page: 908
  ident: bb0170
  article-title: Diarylborinic acid-catalyzed, site-selective sulfation of carbohydrate derivatives
  publication-title: The Journal of Organic Chemistry
– volume: 359
  start-page: 2674
  year: 2008
  end-page: 2684
  ident: bb0060
  article-title: Outbreak of adverse reactions associated with contaminated heparin
  publication-title: New England Journal of Medicine
– volume: 128
  start-page: 135
  year: 1997
  end-page: 138
  ident: bb0055
  article-title: Hypothesis: Is soluble P-selectin a new marker of platelet activation?
  publication-title: Atherosclerosis
– volume: 283
  year: 2022
  ident: bb0130
  article-title: Glycosaminoglycan-like sulfated polysaccharides from Vibrio diabolicus bacterium: Semi-synthesis and characterization
  publication-title: Carbohydrate Polymers
– volume: 6
  year: 2020
  ident: bb0200
  article-title: Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice
  publication-title: Science Advances
– volume: 234
  year: 2022
  ident: bb0430
  article-title: Chemical synthesis and pharmacological properties of heparin pentasaccharide analogues
  publication-title: European Journal of Medicinal Chemistry
– volume: 9
  year: 2017
  ident: bb0405
  article-title: Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins
  publication-title: Science Translational Medicine
– volume: 12
  start-page: 1157
  year: 2011
  end-page: 1170
  ident: bb0220
  article-title: Enoxaparin: A pharmacologic and clinical review
  publication-title: Expert Opinion on Pharmacotherapy
– volume: 111
  start-page: 4871
  year: 2008
  end-page: 4879
  ident: bb0100
  article-title: Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: Focus on new anticoagulant agents
  publication-title: Blood
– volume: 11
  start-page: 9623
  year: 2020
  end-page: 9629
  ident: bb0210
  article-title: Heparin reversal by an oligoethylene glycol functionalized guanidinocalixarene
  publication-title: Chemical Science
– volume: 58
  start-page: 225
  year: 2013
  end-page: 230
  ident: bb0395
  article-title: Sulfation, anticoagulant and antioxidant activities of polysaccharide from green algae enteromorpha linza
  publication-title: International Journal of Biological Macromolecules
– volume: 144
  year: 2024
  ident: bb0080
  article-title: Recent advance in chemistry modified methods of natural polysaccharides and their applications
  publication-title: Trends in Food Science & Technology
– volume: 133
  start-page: 11
  year: 2019
  end-page: 20
  ident: bb0420
  article-title: Structural characterization and immunostimulatory activity of a novel polysaccharide isolated with subcritical water from Sagittaria sagittifolia L
  publication-title: International Journal of Biological Macromolecules
– volume: 39
  year: 2020
  ident: bb0260
  article-title: From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors
  publication-title: Blood Reviews
– volume: 124
  year: 2021
  ident: bb0410
  article-title: Rheological and clot microstructure evaluation of heparin neutralization by UHRA and protamine
  publication-title: Journal of the Mechanical Behavior of Biomedical Materials
– volume: 11
  start-page: 3102
  year: 2020
  ident: bb0245
  article-title: Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
  publication-title: Nature Communications
– volume: 31
  start-page: 335
  year: 2019
  end-page: 344
  ident: bb0375
  article-title: Heparin-induced thrombocytopenia and cardiac surgery
  publication-title: Seminars in Thoracic and Cardiovascular Surgery
– volume: 102
  start-page: 8647
  year: 2018
  end-page: 8660
  ident: bb0065
  article-title: Heparin: Role in protein purification and substitution with animal-component free material
  publication-title: Applied Microbiology and Biotechnology
– volume: 78
  start-page: 4899
  year: 2021
  end-page: 4918
  ident: bb0345
  article-title: Sulfated xanthan: Synthesis, characterization and biological evaluation
  publication-title: Polymer Bulletin
– volume: 66
  start-page: 289
  year: 2006
  end-page: 297
  ident: bb0335
  article-title: Screening, characterization and flocculating property of carbohydrate polymer from newly isolated
  publication-title: Carbohydrate Polymers
– volume: 120
  start-page: 1371
  year: 2020
  end-page: 1383
  ident: bb0035
  article-title: The anticoagulant and nonanticoagulant properties of heparin
  publication-title: Thrombosis and Haemostasis
– volume: 2
  start-page: 549
  year: 2018
  end-page: 558
  ident: bb0110
  article-title: Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors
  publication-title: Blood Advances
– volume: 11
  start-page: 1128
  year: 2013
  end-page: 1136
  ident: bb0140
  article-title: A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparin anticoagulant activity
  publication-title: Journal of Thrombosis and Haemostasis
– volume: 141
  start-page: e24S
  year: 2012
  end-page: e43S
  ident: bb0150
  article-title: Parenteral anticoagulants
  publication-title: Chest
– volume: 136
  start-page: 911
  year: 2019
  end-page: 919
  ident: bb0165
  article-title: Characterisation of chitosan molecular weight distribution by multi-detection asymmetric flow-field flow fractionation (AF4) and SEC
  publication-title: International Journal of Biological Macromolecules
– volume: 18
  start-page: 709
  year: 2022
  end-page: 718
  ident: bb0125
  article-title: Pretreatment with heparin in patients with ST-segment elevation myocardial infarction: A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)
  publication-title: EuroIntervention
– volume: 16
  year: 2015
  ident: bb0190
  article-title: Anticoagulation drug therapy: A review
  publication-title: Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health
– volume: 400
  start-page: 1777
  year: 2022
  end-page: 1787
  ident: bb0050
  article-title: Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): An open-label, multicentre, randomised, controlled trial
  publication-title: The Lancet
– volume: 115
  start-page: 3378
  year: 2005
  end-page: 3384
  ident: bb0155
  article-title: Platelets in inflammation and atherogenesis
  publication-title: The Journal of Clinical Investigation
– volume: 378
  start-page: 693
  year: 2011
  end-page: 703
  ident: bb0300
  article-title: Intravenous enoxaparin or unfractionated heparin in primary percutaneous coronary intervention for ST-elevation myocardial infarction: The international randomised open-label ATOLL trial
  publication-title: The Lancet
– volume: 43
  start-page: 964
  year: 2015
  end-page: 970
  ident: bb0185
  article-title: Heparinase digestion-based disaccharide composition analysis of heparin and heparinoid drugs
  publication-title: Chinese Journal of Analytical Chemistry
– volume: 31
  start-page: 478
  year: 2011
  end-page: 492
  ident: bb0400
  article-title: Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor
  publication-title: Journal of Thrombosis and Thrombolysis
– volume: 83
  start-page: 575
  year: 2007
  end-page: 582
  ident: bb0005
  article-title: Heparin induced thrombocytopenia: Diagnosis and management update
  publication-title: Postgraduate Medical Journal
– volume: 332
  start-page: 75
  year: 2001
  end-page: 83
  ident: bb0215
  article-title: Anticoagulant properties of dextranmethylcarboxylate benzylamide sulfate (DMCBSu); A new generation of bioactive functionalized dextran
  publication-title: Carbohydrate Research
– volume: 213
  year: 2022
  ident: bb0355
  article-title: Polysaccharide-based layer-by-layer nanoarchitectonics with sulfated chitosan for tuning anti-thrombogenic properties
  publication-title: Colloids and Surfaces B: Biointerfaces
– volume: 34
  year: 2022
  ident: bb0255
  article-title: Porous polymers as universal reversal agents for heparin anticoagulants through an inclusion–sequestration mechanism
  publication-title: Advanced Materials
– volume: 20
  start-page: 866
  year: 2022
  end-page: 876
  ident: bb0310
  article-title: A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation
  publication-title: Journal of Thrombosis and Haemostasis
– volume: 6
  start-page: 1259
  year: 2013
  end-page: 1264
  ident: bb0225
  article-title: Sulfated modification and anti-tumor activity of laminarin
  publication-title: Experimental and Therapeutic Medicine
– volume: 90
  start-page: 1804
  year: 2012
  end-page: 1810
  ident: bb0340
  article-title: Chemical characteristic of an anticoagulant-active sulfated polysaccharide from
  publication-title: Carbohydrate Polymers
– volume: 9
  start-page: 1071
  year: 2014
  end-page: 1080
  ident: bb0250
  article-title: Total synthesis of anticoagulant pentasaccharide fondaparinux
  publication-title: ChemMedChem
– volume: 13
  year: 2023
  ident: bb0330
  article-title: Exogenous GR24 inhibits strawberry tillering by affecting the phytohormone signaling and sugar metabolism pathways
  publication-title: Agronomy
– volume: 39
  start-page: 398
  year: 2016
  end-page: 408
  ident: bb0235
  article-title: Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro
  publication-title: Archives of Pharmacal Research
– volume: 295
  year: 2022
  ident: bb0205
  article-title: Biosynthesis of non-sulfated high-molecular-weight glycosaminoglycans and specific-sized oligosaccharides
  publication-title: Carbohydrate Polymers
– volume: 6
  start-page: 168
  year: 2005
  end-page: 173
  ident: bb0030
  article-title: Molecular weight determination of heparin and dermatan sulfate by size exclusion chromatography with a triple detector array
  publication-title: Biomacromolecules
– volume: 36
  start-page: 9
  year: 2016
  end-page: 14
  ident: bb0290
  article-title: Tissue factor pathway inhibitor
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 131
  start-page: 18750
  year: 2019
  end-page: 18756
  ident: bb0325
  article-title: Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly
  publication-title: Angewandte Chemie
– volume: 14
  start-page: 1135
  year: 2016
  end-page: 1145
  ident: bb0070
  article-title: The design and synthesis of new synthetic low-molecular-weight heparins
  publication-title: Journal of Thrombosis and Haemostasis
– volume: 21
  start-page: 2595
  year: 2020
  end-page: 2621
  ident: bb0240
  article-title: Targeting biological polyanions in blood: Strategies toward the design of therapeutics
  publication-title: Biomacromolecules
– volume: 340
  year: 2024
  ident: bb2350
  article-title: Application of MALDI-MS for characterization of fucoidan hydrolysates and screening of
  publication-title: Carbohydrate Polymers
– volume: 28
  year: 2023
  ident: bb0020
  article-title: Fondaparinux sodium: Recent advances in the management of thrombosis
  publication-title: Journal of Cardiovascular Pharmacology and Therapeutics
– volume: 2019
  year: 2019
  ident: bb0120
  article-title: Advances in chemical synthesis of fondaparinux
  publication-title: Journal of Chemistry
– volume: 174
  start-page: 669
  year: 2017
  end-page: 676
  ident: bb0415
  article-title: Sulfated polysaccharide from
  publication-title: Carbohydrate Polymers
– volume: 25
  start-page: 1514
  year: 2011
  end-page: 1520
  ident: bb0160
  article-title: FTIR-ATR spectroscopy as a tool for polysaccharide identification in edible brown and red seaweeds
  publication-title: Food Hydrocolloids
– volume: 7
  year: 2021
  ident: bb0180
  article-title: Snake extract–laden hemostatic bioadhesive gel cross-linked by visible light
  publication-title: Science Advances
– volume: 16
  start-page: 17267
  year: 2024
  end-page: 17284
  ident: bb0270
  article-title: Hemoadhican-based bioabsorbable hydrogel for preventing postoperative adhesions
  publication-title: ACS Applied Materials & Interfaces
– volume: 58
  start-page: 515
  year: 2014
  ident: bb0315
  article-title: Overview of the coagulation system
  publication-title: Indian Journal of Anaesthesia
– volume: 8
  start-page: 29
  year: 2013
  end-page: 42
  ident: bb0380
  article-title: Use of FT-IR spectra and PCA to the bulk characterization of cell wall residues of fruits and vegetables along a fraction process
  publication-title: Food Biophysics
– volume: 14
  start-page: 188
  issue: 4
  year: 2010
  ident: 10.1016/j.carbpol.2024.122782_bb0370
  article-title: Newer antithrombotic drugs
  publication-title: Indian Journal of Critical Care Medicine: Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
  doi: 10.4103/0972-5229.76083
– volume: 39
  start-page: 398
  issue: 3
  year: 2016
  ident: 10.1016/j.carbpol.2024.122782_bb0235
  article-title: Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro
  publication-title: Archives of Pharmacal Research
  doi: 10.1007/s12272-016-0708-x
– volume: 31
  start-page: 335
  issue: 3
  year: 2019
  ident: 10.1016/j.carbpol.2024.122782_bb0375
  article-title: Heparin-induced thrombocytopenia and cardiac surgery
  publication-title: Seminars in Thoracic and Cardiovascular Surgery
  doi: 10.1053/j.semtcvs.2018.10.011
– volume: 107
  start-page: 3876
  issue: 10
  year: 2006
  ident: 10.1016/j.carbpol.2024.122782_bb0360
  article-title: Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism
  publication-title: Blood
  doi: 10.1182/blood-2005-07-3043
– volume: 301
  year: 2023
  ident: 10.1016/j.carbpol.2024.122782_bb0040
  article-title: Preparation, characterization and immunomodulatory effects of unsaturated sulfated oligoguluronic acid
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2022.120370
– volume: 66
  start-page: 289
  issue: 3
  year: 2006
  ident: 10.1016/j.carbpol.2024.122782_bb0335
  article-title: Screening, characterization and flocculating property of carbohydrate polymer from newly isolated Enterobacter cloacae WD7
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2006.03.011
– volume: 261
  year: 2024
  ident: 10.1016/j.carbpol.2024.122782_bb0090
  article-title: Effect of subcritical water temperature on the structure, antioxidant activity and immune activity of polysaccharides from Glycyrrhiza inflata Batalin
  publication-title: International Journal of Biological Macromolecules
  doi: 10.1016/j.ijbiomac.2024.129591
– volume: 8
  start-page: 29
  issue: 1
  year: 2013
  ident: 10.1016/j.carbpol.2024.122782_bb0380
  article-title: Use of FT-IR spectra and PCA to the bulk characterization of cell wall residues of fruits and vegetables along a fraction process
  publication-title: Food Biophysics
  doi: 10.1007/s11483-012-9279-7
– volume: 340
  year: 2024
  ident: 10.1016/j.carbpol.2024.122782_bb2350
  article-title: Application of MALDI-MS for characterization of fucoidan hydrolysates and screening of endo-fucoidanase activity
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2024.122317
– volume: 202
  start-page: 498
  issue: 4931
  year: 1964
  ident: 10.1016/j.carbpol.2024.122782_bb0275
  article-title: An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier
  publication-title: Nature
  doi: 10.1038/202498a0
– volume: 361
  start-page: 155
  year: 2012
  ident: 10.1016/j.carbpol.2024.122782_bb0285
  article-title: An alternative route for fondaparinux sodium synthesis via selective hydrogenations and sulfation of appropriate pentasaccharides
  publication-title: Carbohydrate Research
  doi: 10.1016/j.carres.2012.08.020
– volume: 13
  start-page: 249
  issue: 2
  year: 2003
  ident: 10.1016/j.carbpol.2024.122782_bb0365
  article-title: Heparin thromboprophylaxis in gastric bypass surgery
  publication-title: Obesity Surgery
  doi: 10.1381/096089203764467153
– volume: 25
  start-page: 2095
  issue: 12
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0025
  article-title: Advances in the preparation and synthesis of heparin and related products
  publication-title: Drug Discovery Today
  doi: 10.1016/j.drudis.2020.09.011
– volume: 155
  start-page: 1460
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0085
  article-title: Flow synthesis, characterization, anticoagulant activity of xylan sulfate from sugarcane bagasse
  publication-title: International Journal of Biological Macromolecules
  doi: 10.1016/j.ijbiomac.2019.11.124
– volume: 58
  start-page: 225
  year: 2013
  ident: 10.1016/j.carbpol.2024.122782_bb0395
  article-title: Sulfation, anticoagulant and antioxidant activities of polysaccharide from green algae enteromorpha linza
  publication-title: International Journal of Biological Macromolecules
  doi: 10.1016/j.ijbiomac.2013.04.005
– volume: 31
  start-page: 478
  issue: 4
  year: 2011
  ident: 10.1016/j.carbpol.2024.122782_bb0400
  article-title: Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor
  publication-title: Journal of Thrombosis and Thrombolysis
  doi: 10.1007/s11239-011-0551-3
– volume: 118
  start-page: 361
  issue: 3
  year: 2006
  ident: 10.1016/j.carbpol.2024.122782_bb0230
  article-title: Increased expression of platelet P-selectin and formation of platelet–leukocyte aggregates in blood from patients treated with unfractionated heparin plus eptifibatide compared with bivalirudin
  publication-title: Thrombosis Research
  doi: 10.1016/j.thromres.2005.07.020
– volume: 132
  start-page: 533
  issue: 5
  year: 2018
  ident: 10.1016/j.carbpol.2024.122782_bb0320
  article-title: Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation
  publication-title: Blood
  doi: 10.1182/blood-2017-05-785253
– volume: 1
  start-page: 1471
  issue: 7
  year: 2003
  ident: 10.1016/j.carbpol.2024.122782_bb0095
  article-title: Heparin-induced thrombocytopenia
  publication-title: Journal of Thrombosis and Haemostasis
  doi: 10.1046/j.1538-7836.2003.00270.x
– volume: 15
  start-page: 6604
  issue: 4
  year: 2021
  ident: 10.1016/j.carbpol.2024.122782_bb0115
  article-title: Biological mediator-propelled nanosweeper for nonpharmaceutical thrombus therapy
  publication-title: ACS Nano
  doi: 10.1021/acsnano.0c09939
– volume: 234
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0430
  article-title: Chemical synthesis and pharmacological properties of heparin pentasaccharide analogues
  publication-title: European Journal of Medicinal Chemistry
  doi: 10.1016/j.ejmech.2022.114256
– volume: 133
  start-page: 11
  year: 2019
  ident: 10.1016/j.carbpol.2024.122782_bb0420
  article-title: Structural characterization and immunostimulatory activity of a novel polysaccharide isolated with subcritical water from Sagittaria sagittifolia L
  publication-title: International Journal of Biological Macromolecules
  doi: 10.1016/j.ijbiomac.2019.04.077
– volume: 43
  start-page: 964
  issue: 7
  year: 2015
  ident: 10.1016/j.carbpol.2024.122782_bb0185
  article-title: Heparinase digestion-based disaccharide composition analysis of heparin and heparinoid drugs
  publication-title: Chinese Journal of Analytical Chemistry
  doi: 10.1016/S1872-2040(15)60835-0
– volume: 120
  start-page: 1371
  issue: 10
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0035
  article-title: The anticoagulant and nonanticoagulant properties of heparin
  publication-title: Thrombosis and Haemostasis
  doi: 10.1055/s-0040-1715460
– volume: 69
  start-page: 3667
  issue: 12
  year: 2021
  ident: 10.1016/j.carbpol.2024.122782_bb0390
  article-title: Preparation and gut microbiota modulatory property of the oligosaccharide riclinoctaose
  publication-title: Journal of Agricultural and Food Chemistry
  doi: 10.1021/acs.jafc.0c07783
– volume: 25
  start-page: 1514
  issue: 6
  year: 2011
  ident: 10.1016/j.carbpol.2024.122782_bb0160
  article-title: FTIR-ATR spectroscopy as a tool for polysaccharide identification in edible brown and red seaweeds
  publication-title: Food Hydrocolloids
  doi: 10.1016/j.foodhyd.2011.02.009
– volume: 124
  year: 2021
  ident: 10.1016/j.carbpol.2024.122782_bb0410
  article-title: Rheological and clot microstructure evaluation of heparin neutralization by UHRA and protamine
  publication-title: Journal of the Mechanical Behavior of Biomedical Materials
  doi: 10.1016/j.jmbbm.2021.104851
– volume: 78
  start-page: 4899
  issue: 9
  year: 2021
  ident: 10.1016/j.carbpol.2024.122782_bb0345
  article-title: Sulfated xanthan: Synthesis, characterization and biological evaluation
  publication-title: Polymer Bulletin
  doi: 10.1007/s00289-020-03344-8
– volume: 53
  start-page: 9876
  issue: 37
  year: 2014
  ident: 10.1016/j.carbpol.2024.122782_bb0075
  article-title: Synthesis of the heparin-based anticoagulant drug fondaparinux
  publication-title: Angewandte Chemie International Edition
  doi: 10.1002/anie.201404154
– volume: 84
  start-page: 900
  issue: 2
  year: 2019
  ident: 10.1016/j.carbpol.2024.122782_bb0170
  article-title: Diarylborinic acid-catalyzed, site-selective sulfation of carbohydrate derivatives
  publication-title: The Journal of Organic Chemistry
  doi: 10.1021/acs.joc.8b02792
– volume: 9
  issue: 406
  year: 2017
  ident: 10.1016/j.carbpol.2024.122782_bb0405
  article-title: Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins
  publication-title: Science Translational Medicine
  doi: 10.1126/scitranslmed.aan5954
– volume: 71
  start-page: 559
  issue: 4
  year: 2008
  ident: 10.1016/j.carbpol.2024.122782_bb0280
  article-title: Structural characterization of cold extracted fraction of soluble sulfated polysaccharide from red seaweed Gracilaria birdiae
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2007.06.026
– volume: 136
  start-page: 911
  year: 2019
  ident: 10.1016/j.carbpol.2024.122782_bb0165
  article-title: Characterisation of chitosan molecular weight distribution by multi-detection asymmetric flow-field flow fractionation (AF4) and SEC
  publication-title: International Journal of Biological Macromolecules
  doi: 10.1016/j.ijbiomac.2019.06.122
– volume: 11
  start-page: 3102
  issue: 1
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0245
  article-title: Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
  publication-title: Nature Communications
  doi: 10.1038/s41467-020-16924-z
– volume: 332
  start-page: 75
  issue: 1
  year: 2001
  ident: 10.1016/j.carbpol.2024.122782_bb0215
  article-title: Anticoagulant properties of dextranmethylcarboxylate benzylamide sulfate (DMCBSu); A new generation of bioactive functionalized dextran
  publication-title: Carbohydrate Research
  doi: 10.1016/S0008-6215(01)00066-0
– volume: 11
  start-page: 9623
  issue: 35
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0210
  article-title: Heparin reversal by an oligoethylene glycol functionalized guanidinocalixarene
  publication-title: Chemical Science
  doi: 10.1039/D0SC03922E
– volume: 400
  start-page: 1777
  issue: 10365
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0050
  article-title: Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): An open-label, multicentre, randomised, controlled trial
  publication-title: The Lancet
  doi: 10.1016/S0140-6736(22)02128-6
– start-page: 511
  year: 2014
  ident: 10.1016/j.carbpol.2024.122782_bb0105
  article-title: Chapter 60—Autoantibodies in heparin-induced thrombocytopenia
– volume: 115
  start-page: 615
  issue: 03
  year: 2016
  ident: 10.1016/j.carbpol.2024.122782_bb0175
  article-title: Platelet-specific markers are associated with monocyte-platelet aggregate formation and thrombin generation potential in advanced atherosclerosis
  publication-title: Thrombosis and Haemostasis
  doi: 10.1160/th15-07-0598
– volume: 20
  issue: 3
  year: 2015
  ident: 10.1016/j.carbpol.2024.122782_bb0045
  article-title: Determination of the molecular weight of low-molecular-weight heparins by using high-pressure size exclusion chromatography on line with a triple detector array and conventional methods
  publication-title: Molecules
  doi: 10.3390/molecules20035085
– volume: 79
  start-page: 240
  issue: 5
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0425
  article-title: Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
  publication-title: Cellular and Molecular Life Sciences
  doi: 10.1007/s00018-022-04257-7
– volume: 359
  start-page: 2674
  issue: 25
  year: 2008
  ident: 10.1016/j.carbpol.2024.122782_bb0060
  article-title: Outbreak of adverse reactions associated with contaminated heparin
  publication-title: New England Journal of Medicine
  doi: 10.1056/NEJMoa0806450
– volume: 39
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0260
  article-title: From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors
  publication-title: Blood Reviews
  doi: 10.1016/j.blre.2019.100615
– volume: 111
  start-page: 4871
  issue: 10
  year: 2008
  ident: 10.1016/j.carbpol.2024.122782_bb0100
  article-title: Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: Focus on new anticoagulant agents
  publication-title: Blood
  doi: 10.1182/blood-2007-10-120543
– volume: 11
  start-page: 1128
  issue: 6
  year: 2013
  ident: 10.1016/j.carbpol.2024.122782_bb0140
  article-title: A chemically-modified inactive antithrombin as a potent antagonist of fondaparinux and heparin anticoagulant activity
  publication-title: Journal of Thrombosis and Haemostasis
  doi: 10.1111/jth.12249
– volume: 9
  start-page: 1071
  issue: 5
  year: 2014
  ident: 10.1016/j.carbpol.2024.122782_bb0250
  article-title: Total synthesis of anticoagulant pentasaccharide fondaparinux
  publication-title: ChemMedChem
  doi: 10.1002/cmdc.201400019
– volume: 128
  start-page: 135
  issue: 2
  year: 1997
  ident: 10.1016/j.carbpol.2024.122782_bb0055
  article-title: Hypothesis: Is soluble P-selectin a new marker of platelet activation?
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(96)05980-1
– volume: 20
  start-page: 866
  issue: 4
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0310
  article-title: A rapid, sensitive, and specific assay to measure TF activity based on chromogenic determination of thrombin generation
  publication-title: Journal of Thrombosis and Haemostasis
  doi: 10.1111/jth.15606
– volume: 174
  start-page: 669
  year: 2017
  ident: 10.1016/j.carbpol.2024.122782_bb0415
  article-title: Sulfated polysaccharide from Cyclocarya paliurus enhances the immunomodulatory activity of macrophages
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2017.07.009
– volume: 144
  year: 2024
  ident: 10.1016/j.carbpol.2024.122782_bb0080
  article-title: Recent advance in chemistry modified methods of natural polysaccharides and their applications
  publication-title: Trends in Food Science & Technology
  doi: 10.1016/j.tifs.2023.104317
– volume: 378
  start-page: 693
  issue: 9792
  year: 2011
  ident: 10.1016/j.carbpol.2024.122782_bb0300
  article-title: Intravenous enoxaparin or unfractionated heparin in primary percutaneous coronary intervention for ST-elevation myocardial infarction: The international randomised open-label ATOLL trial
  publication-title: The Lancet
  doi: 10.1016/S0140-6736(11)60876-3
– volume: 116
  start-page: 1210
  issue: 6
  year: 2013
  ident: 10.1016/j.carbpol.2024.122782_bb0145
  article-title: Heparin sensitivity and resistance: Management during cardiopulmonary bypass
  publication-title: Anesthesia & Analgesia
  doi: 10.1213/ANE.0b013e31827e4e62
– volume: 2
  start-page: 549
  issue: 5
  year: 2018
  ident: 10.1016/j.carbpol.2024.122782_bb0110
  article-title: Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors
  publication-title: Blood Advances
  doi: 10.1182/bloodadvances.2018016337
– volume: 21
  start-page: 2595
  issue: 7
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0240
  article-title: Targeting biological polyanions in blood: Strategies toward the design of therapeutics
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.0c00654
– volume: 18
  start-page: 709
  issue: 9
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0125
  article-title: Pretreatment with heparin in patients with ST-segment elevation myocardial infarction: A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)
  publication-title: EuroIntervention
  doi: 10.4244/EIJ-D-22-00432
– volume: 16
  start-page: 17267
  issue: 14
  year: 2024
  ident: 10.1016/j.carbpol.2024.122782_bb0270
  article-title: Hemoadhican-based bioabsorbable hydrogel for preventing postoperative adhesions
  publication-title: ACS Applied Materials & Interfaces
  doi: 10.1021/acsami.4c01088
– volume: 14
  start-page: 1135
  issue: 6
  year: 2016
  ident: 10.1016/j.carbpol.2024.122782_bb0070
  article-title: The design and synthesis of new synthetic low-molecular-weight heparins
  publication-title: Journal of Thrombosis and Haemostasis
  doi: 10.1111/jth.13312
– volume: 164
  start-page: 1234
  issue: 6
  year: 2018
  ident: 10.1016/j.carbpol.2024.122782_bb0350
  article-title: Extended versus conventional thromboprophylaxis after major abdominal and pelvic surgery: Systematic review and meta-analysis of randomized clinical trials
  publication-title: Surgery
  doi: 10.1016/j.surg.2018.05.028
– volume: 30
  start-page: 119
  issue: 2
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0385
  article-title: Transferrin plays a central role in coagulation balance by interacting with clotting factors
  publication-title: Cell Research
  doi: 10.1038/s41422-019-0260-6
– volume: 83
  start-page: 575
  issue: 983
  year: 2007
  ident: 10.1016/j.carbpol.2024.122782_bb0005
  article-title: Heparin induced thrombocytopenia: Diagnosis and management update
  publication-title: Postgraduate Medical Journal
  doi: 10.1136/pgmj.2007.059188
– volume: 283
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0130
  article-title: Glycosaminoglycan-like sulfated polysaccharides from Vibrio diabolicus bacterium: Semi-synthesis and characterization
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2021.119054
– volume: 9
  start-page: 12
  issue: s1
  year: 2011
  ident: 10.1016/j.carbpol.2024.122782_bb0015
  article-title: Recent progress in anticoagulant therapy: Oral direct inhibitors of thrombin and factor Xa
  publication-title: Journal of Thrombosis and Haemostasis
  doi: 10.1111/j.1538-7836.2011.04321.x
– volume: 12
  start-page: 1157
  issue: 7
  year: 2011
  ident: 10.1016/j.carbpol.2024.122782_bb0220
  article-title: Enoxaparin: A pharmacologic and clinical review
  publication-title: Expert Opinion on Pharmacotherapy
  doi: 10.1517/14656566.2011.570261
– volume: 141
  start-page: e24S
  issue: 2 Suppl
  year: 2012
  ident: 10.1016/j.carbpol.2024.122782_bb0150
  article-title: Parenteral anticoagulants
  publication-title: Chest
  doi: 10.1378/chest.11-2291
– volume: 115
  start-page: 3378
  issue: 12
  year: 2005
  ident: 10.1016/j.carbpol.2024.122782_bb0155
  article-title: Platelets in inflammation and atherogenesis
  publication-title: The Journal of Clinical Investigation
  doi: 10.1172/JCI27196
– volume: 50
  start-page: 31
  issue: 1
  year: 2012
  ident: 10.1016/j.carbpol.2024.122782_bb0135
  article-title: Synthesis and anticoagulant activity of the quaternary ammonium chitosan sulfates
  publication-title: International Journal of Biological Macromolecules
  doi: 10.1016/j.ijbiomac.2011.09.024
– volume: 295
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0205
  article-title: Biosynthesis of non-sulfated high-molecular-weight glycosaminoglycans and specific-sized oligosaccharides
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2022.119829
– volume: 34
  issue: 23
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0255
  article-title: Porous polymers as universal reversal agents for heparin anticoagulants through an inclusion–sequestration mechanism
  publication-title: Advanced Materials
  doi: 10.1002/adma.202200549
– volume: 28
  year: 2023
  ident: 10.1016/j.carbpol.2024.122782_bb0020
  article-title: Fondaparinux sodium: Recent advances in the management of thrombosis
  publication-title: Journal of Cardiovascular Pharmacology and Therapeutics
  doi: 10.1177/10742484221145010
– volume: 13
  issue: 12
  year: 2023
  ident: 10.1016/j.carbpol.2024.122782_bb0330
  article-title: Exogenous GR24 inhibits strawberry tillering by affecting the phytohormone signaling and sugar metabolism pathways
  publication-title: Agronomy
  doi: 10.3390/agronomy13123078
– volume: 6
  start-page: 168
  issue: 1
  year: 2005
  ident: 10.1016/j.carbpol.2024.122782_bb0030
  article-title: Molecular weight determination of heparin and dermatan sulfate by size exclusion chromatography with a triple detector array
  publication-title: Biomacromolecules
  doi: 10.1021/bm049693s
– volume: 6
  issue: 49
  year: 2020
  ident: 10.1016/j.carbpol.2024.122782_bb0200
  article-title: Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice
  publication-title: Science Advances
  doi: 10.1126/sciadv.abd0130
– volume: 9
  start-page: 765
  issue: 12
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0295
  article-title: Hyper-branched cyclodextrin-based polymers as anticoagulant agents: In vitro and in vivo studies
  publication-title: Bioengineering
  doi: 10.3390/bioengineering9120765
– volume: 131
  start-page: 18750
  issue: 51
  year: 2019
  ident: 10.1016/j.carbpol.2024.122782_bb0325
  article-title: Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly
  publication-title: Angewandte Chemie
  doi: 10.1002/ange.201908805
– volume: 213
  year: 2022
  ident: 10.1016/j.carbpol.2024.122782_bb0355
  article-title: Polysaccharide-based layer-by-layer nanoarchitectonics with sulfated chitosan for tuning anti-thrombogenic properties
  publication-title: Colloids and Surfaces B: Biointerfaces
  doi: 10.1016/j.colsurfb.2022.112359
– volume: 7
  issue: 29
  year: 2021
  ident: 10.1016/j.carbpol.2024.122782_bb0180
  article-title: Snake extract–laden hemostatic bioadhesive gel cross-linked by visible light
  publication-title: Science Advances
  doi: 10.1126/sciadv.abf9635
– volume: 6
  start-page: 1259
  issue: 5
  year: 2013
  ident: 10.1016/j.carbpol.2024.122782_bb0225
  article-title: Sulfated modification and anti-tumor activity of laminarin
  publication-title: Experimental and Therapeutic Medicine
  doi: 10.3892/etm.2013.1277
– volume: 2019
  year: 2019
  ident: 10.1016/j.carbpol.2024.122782_bb0120
  article-title: Advances in chemical synthesis of fondaparinux
  publication-title: Journal of Chemistry
  doi: 10.1155/2019/9545297
– volume: 58
  start-page: 515
  issue: 5
  year: 2014
  ident: 10.1016/j.carbpol.2024.122782_bb0315
  article-title: Overview of the coagulation system
  publication-title: Indian Journal of Anaesthesia
  doi: 10.4103/0019-5049.144643
– volume: 51
  start-page: 2037
  issue: 10
  year: 2013
  ident: 10.1016/j.carbpol.2024.122782_bb0195
  article-title: A novel method for the direct determination of heparin concentration during cardiopulmonary bypass surgery
  publication-title: Clinical Chemistry and Laboratory Medicine (CCLM)
  doi: 10.1515/cclm-2013-0278
– volume: 90
  start-page: 1804
  issue: 4
  year: 2012
  ident: 10.1016/j.carbpol.2024.122782_bb0340
  article-title: Chemical characteristic of an anticoagulant-active sulfated polysaccharide from Enteromorpha clathrata
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2012.07.077
– volume: 16
  issue: 1
  year: 2015
  ident: 10.1016/j.carbpol.2024.122782_bb0190
  article-title: Anticoagulation drug therapy: A review
  publication-title: Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health
  doi: 10.5811/westjem.2014.12.22933
– volume: 152
  start-page: 343
  year: 2016
  ident: 10.1016/j.carbpol.2024.122782_bb0265
  article-title: Antithrombotic activities of fucosylated chondroitin sulfates and their depolymerized fragments from two sea cucumbers
  publication-title: Carbohydrate Polymers
  doi: 10.1016/j.carbpol.2016.06.106
– volume: 102
  start-page: 8647
  issue: 20
  year: 2018
  ident: 10.1016/j.carbpol.2024.122782_bb0065
  article-title: Heparin: Role in protein purification and substitution with animal-component free material
  publication-title: Applied Microbiology and Biotechnology
  doi: 10.1007/s00253-018-9263-3
– volume: 29
  start-page: 503
  issue: 4
  year: 2010
  ident: 10.1016/j.carbpol.2024.122782_bb0305
  article-title: Severe bleeding secondary to misuse of fondaparinux: A case report
  publication-title: Journal of Thrombosis and Thrombolysis
  doi: 10.1007/s11239-009-0376-5
– volume: 173
  start-page: 1869
  issue: 6
  year: 1995
  ident: 10.1016/j.carbpol.2024.122782_bb0010
  article-title: Heparin levels to guide thromboembolism prophylaxis during pregnancy
  publication-title: American Journal of Obstetrics and Gynecology
  doi: 10.1016/0002-9378(95)90443-3
– volume: 36
  start-page: 9
  issue: 1
  year: 2016
  ident: 10.1016/j.carbpol.2024.122782_bb0290
  article-title: Tissue factor pathway inhibitor
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
  doi: 10.1161/ATVBAHA.115.305996
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Snippet Heparins are sulfated polysaccharides with a heterogeneous mixture derived from animal tissues, subject to supply limitations and the risk of animal virus...
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StartPage 122782
SubjectTerms animal viruses
Animals
anticoagulant activity
Anticoagulant effect
anticoagulants
Anticoagulants - chemistry
Anticoagulants - pharmacology
blood
Blood Coagulation - drug effects
coagulation
Fourier transform infrared spectroscopy
heparin
Heparin - chemistry
Heparin - pharmacology
Humans
Male
Mice
molecular weight
Oligosaccharides - chemical synthesis
Oligosaccharides - chemistry
Oligosaccharides - pharmacology
Riclinoctaose
risk
Sulfated oligosaccharide
Sulfates - chemistry
sulfur
Sulfur trioxide-trimethylamine complexes
synthesis
thrombocytopenia
thrombosis
Thrombosis - chemically induced
Thrombosis - drug therapy
Thrombosis - prevention & control
Title Preparation and structural characterization of a sulfated octasaccharide with heparin-like anticoagulant activity
URI https://dx.doi.org/10.1016/j.carbpol.2024.122782
https://www.ncbi.nlm.nih.gov/pubmed/39487001
https://www.proquest.com/docview/3123550148
https://www.proquest.com/docview/3154157965
Volume 347
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