Natural diterpenoids in dermatology: Multifunctional roles and therapeutic potential for skin diseases

• Published in: Phytomedicine (Stuttgart) Vol. 143; p. 156842
• Main Authors: Li, Chunlin, Ma, Minghua, Liu, Xin, Hu, Yue, Feng, Zhiguang, Zhang, Ruoxi, Wang, Zhenwei, Nian, Hua, Zhu, Jianyong
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 25.07.2025
• Subjects: Animals; biomedical research; camphor; Diterpenes - chemistry; Diterpenes - pharmacology; Diterpenes - therapeutic use; Diterpenoids; drugs; Humans; lemon oil; Mechanism; oils; Oils, Volatile - chemistry; peppermint oil; Pharmacological activity; Phytotherapy; Plant Oils - chemistry; Skin diseases; Skin Diseases - drug therapy; Structure; therapeutics; turpentine; water solubility; MCV; eNOS; MHC; STI; BMDM; CTGF; IFN-γ; VZV; IC50; Skin diseases; EC50; iNOS; Th1; Th17; Th2; PASI; AD; TNF-a; MIC; PKB; PKC; HSV; IL-2; IMQ; PPARγ; IκBα; MMP; ERK1/2; KIT; ROS; PGAM5; cDCs; Bcl-2; UVB; NO; IgA; Pharmacological activity; IgE; DNCB; Mechanism; LPS; HPV; PI3K/Akt; IL-36γ; DCs; SI; pDCs; MAPK2; Structure; GI50; AChE; APCs; PGE2; p21waf1/cip1; TSLP; BRAF; BMDCs; HEK; TRP-1; TRP-2; CU; Th22; JAK; Keap1; Diterpenoids; FAS; ATM; MEK1; HaCaT

Skin disorders are a collection of prevalent and frequent illnesses that have significant impacts on daily life. Currently, a limited number of effective therapeutic drugs are available that fall far short of the clinical needs; most medications usually offer chronic alleviation instead of treatment...