Acetyl‐CoA carboxylase‐1/2 blockade locks dendritic cells in the semimature state associated with FA deprivation by favoring FAO

• Published in: Journal of leukocyte biology Vol. 111; no. 3; pp. 539 - 551
• Main Authors: Nguyen‐Phuong, Thuy, Chung, Hyunwoo, Jang, Jiyun, Kim, Jung‐Sik, Park, Chung‐Gyu
• Format: Journal Article
• Language: English
• Published: United States 01.03.2022
• Subjects: ACC1/2 inhibitor; DCs; FAO; FAS; fatty acid metabolism; maturation resistance; FAS; maturation resistance; DCs; FAO; fatty acid metabolism; ACC1/2 inhibitor

Immunometabolism is rising as an intriguing topic that reveals the connection between immune cell function and metabolic processes. Especially, fatty acid metabolism plays an essential role in the dendritic cells (DCs) during the differentiation and maturation period. We questioned whether regulatio...