Is it time to revisit contraindications to organ donation from donors with a JAK‐2 mutation? Safe use of a liver allograft from a donor with essential thrombocythaemia

• Published in: Transplant international Vol. 28; no. 7; pp. 881 - 883
• Main Authors: Haldar, Debashis, Chen, Frederick, Bryon, Jane, Elsharkawy, Ahmed Mohamed, Perera, M Thamara PR
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2015
• Subjects: Aged; Blood & organ donations; Carcinoma, Hepatocellular - surgery; contraindication to donation; donor malignancy; Donor Selection - methods; Female; Genetic Markers; Humans; Janus Kinase 2 - genetics; Liver cancer; Liver cirrhosis; Liver Neoplasms - surgery; Liver Transplantation; Male; marginal donor; Mortality; Mutation; Patients; Thrombocythemia, Essential - genetics; Tissue Donors; Transplants & implants; marginal donor; contraindication to donation; donor malignancy; liver transplantation

Summary Transplantation can cure end‐stage liver disease and hepatocellular carcinoma. However, the balance of organ demand and provision is heavily tipped to the detriment of patients. Patients awaiting transplantation rely on the greater use of marginal donors that may carry a risk to the recipien...