VASE-encoded peptide modifies NCAM- and L1-mediated neurite outgrowth

Interactions between the neural cell adhesion molecule (NCAM) with NCAM‐expressing neurons (trans‐interaction) stimulate outgrowth of neurites. The extent of NCAM‐triggered neurite outgrowth depends on the presence of 10 amino acids derived from the variable alternatively spliced exon (VASE or π‐exo...

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Published inJournal of neuroscience research Vol. 50; no. 1; pp. 62 - 68
Main Authors Lahrtz, Fritz, Horstkorte, Rüdiger, Cremer, Harold, Schachner, Melitta, Montag, Dirk
Format Journal Article
LanguageEnglish
Published New York John Wiley & Sons, Inc 01.10.1997
Subjects
Alternative Splicing - physiology
Animals
Cell Adhesion Molecules, Neuronal - chemistry
Cell Adhesion Molecules, Neuronal - metabolism
Cells, Cultured
Cerebellum - cytology
Cloning, Molecular
Exons - genetics
Gene Expression - physiology
Immunoglobulins - chemistry
Leukocyte L1 Antigen Complex
Membrane Glycoproteins - metabolism
Mice
Mice, Mutant Strains
NCAM
neurite outgrowth
Neurites - chemistry
Neurites - drug effects
Neurites - physiology
Oligopeptides - genetics
Recombinant Proteins
VASE
π-exon
Online AccessGet full text

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Abstract Interactions between the neural cell adhesion molecule (NCAM) with NCAM‐expressing neurons (trans‐interaction) stimulate outgrowth of neurites. The extent of NCAM‐triggered neurite outgrowth depends on the presence of 10 amino acids derived from the variable alternatively spliced exon (VASE or π‐exon) in the fourth immunoglobulin‐like domain of NCAM (Ig4): NCAM with VASE reduces and without VASE enhances neurite outgrowth in cis‐ or trans‐interaction. We have investigated the role of VASE in neurite outgrowth by characterizing the receptors at the cell surface of cultured cerebellar neurons. Results from experiments with L1 and NCAM antibodies and with cerebellar neurons derived from wild‐type or NCAM‐deficient mice show that substrate‐coated Ig4 with VASE (Ig4+) or without VASE (Ig4−) stimulates neurite outgrowth by a trans‐interaction with L1 and that Ig4− promotes neurite outgrowth more strongly than Ig4+ by a transinteraction with NCAM. J. Neurosci. Res. 50:62–68, 1997. © 1997 Wiley‐Liss, Inc.
AbstractList Interactions between the neural cell adhesion molecule (NCAM) with NCAM‐expressing neurons (trans‐interaction) stimulate outgrowth of neurites. The extent of NCAM‐triggered neurite outgrowth depends on the presence of 10 amino acids derived from the variable alternatively spliced exon (VASE or π‐exon) in the fourth immunoglobulin‐like domain of NCAM (Ig4): NCAM with VASE reduces and without VASE enhances neurite outgrowth in cis‐ or trans‐interaction. We have investigated the role of VASE in neurite outgrowth by characterizing the receptors at the cell surface of cultured cerebellar neurons. Results from experiments with L1 and NCAM antibodies and with cerebellar neurons derived from wild‐type or NCAM‐deficient mice show that substrate‐coated Ig4 with VASE (Ig4+) or without VASE (Ig4−) stimulates neurite outgrowth by a trans‐interaction with L1 and that Ig4− promotes neurite outgrowth more strongly than Ig4+ by a transinteraction with NCAM. J. Neurosci. Res. 50:62–68, 1997. © 1997 Wiley‐Liss, Inc.
Interactions between the neural cell adhesion molecule (NCAM) with NCAM-expressing neurons (transinteraction) stimulate outgrowth of neurites. The extent of NCAM-triggered neurite outgrowth depends on the presence of 10 amino acids derived from the variable alternatively spliced exon (VASE or pi -exon) in the fourth immunoglobulin-like domain of NCAM (Ig4): NCAM with VASE reduces and without VASE enhances neurite outgrowth in cis- or trans-interaction. We have investigated the role of VASE in neurite outgrowth by characterizing the receptors at the cell surface of cultured cerebellar neurons. Results from experiments with L1 and NCAM antibodies and with cerebellar neurons derived from wild-type or NCAM- deficient mice show that substrate-coated Ig4 with VASE (Ig4+) or without VASE (Ig4-) stimulates neurite outgrowth by a trans-interaction with L1 and that Ig4- promotes neurite outgrowth more strongly than Ig4+ by a transinteraction with NCAM.
Interactions between the neural cell adhesion molecule (NCAM) with NCAM-expressing neurons (trans-interaction) stimulate outgrowth of neurites. The extent of NCAM-triggered neurite outgrowth depends on the presence of 10 amino acids derived from the variable alternatively spliced exon (VASE or pi-exon) in the fourth immunoglobulin-like domain of NCAM (Ig4): NCAM with VASE reduces and without VASE enhances neurite outgrowth in cis- or trans-interaction. We have investigated the role of VASE in neurite outgrowth by characterizing the receptors at the cell surface of cultured cerebellar neurons. Results from experiments with L1 and NCAM antibodies and with cerebellar neurons derived from wild-type or NCAM-deficient mice show that substrate-coated Ig4 with VASE (Ig4+) or without VASE (Ig4-) stimulates neurite outgrowth by a trans-interaction with L1 and that Ig4- promotes neurite outgrowth more strongly than Ig4+ by a transinteraction with NCAM.
Author Schachner, Melitta
Horstkorte, Rüdiger
Lahrtz, Fritz
Cremer, Harold
Montag, Dirk
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Cites_doi 10.1002/jnr.490350313
10.1126/science.2999980
10.1083/jcb.127.3.825
10.1111/j.1460-9568.1991.tb00849.x
10.1016/0165-3806(88)90101-0
10.1073/pnas.76.9.4350
10.1038/227680a0
10.1083/jcb.87.2.370
10.1083/jcb.121.6.1409
10.1083/jcb.118.1.177
10.1002/j.1460-2075.1989.tb03389.x
10.1016/0896-6273(88)90158-4
10.1016/0092-8674(95)90421-2
10.1111/j.1471-4159.1992.tb11033.x
10.1016/0896-6273(94)90339-5
10.1146/annurev.iy.06.040188.002121
10.1083/jcb.125.2.427
10.1083/jcb.110.1.193
10.1002/j.1460-2075.1984.tb01753.x
10.1016/0022-2836(78)90297-8
10.1073/pnas.80.18.5762
10.1016/0166-2236(90)90098-U
10.1146/annurev.ne.19.030196.002013
10.1038/334701a0
10.1016/0959-4388(94)90031-0
10.1007/BF00214676
10.1016/0896-6273(92)90197-L
10.1002/jnr.490310102
10.1016/0003-2697(91)90534-Z
10.1038/356791a0
10.1002/j.1460-2075.1984.tb01876.x
10.1038/316728a0
10.1073/pnas.84.21.7753
10.1073/pnas.93.9.4071
10.1002/jnr.490200304
10.1016/0378-1119(85)90120-9
10.1016/0896-6273(89)90048-2
10.1083/jcb.111.5.2089
10.1146/annurev.bi.47.070178.001343
10.1038/367455a0
10.1083/jcb.103.6.2439
10.1016/0896-6273(91)90360-C
10.1111/j.1749-6632.1991.tb15601.x
10.1002/j.1460-2075.1987.tb04837.x
10.1083/jcb.110.1.209
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References Chou PY, Fassman GD (1978): Empirical prediction of protein conformation. Annu Rev Biochem 47: 251-276.
Garnier J, Osguthorpe DJ, Robson B (1978): Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol 120: 97-120.
Small SJ, Akeson R (1990): Expression of the unique NCAM VASE exon is independently regulated in distinct tissues during development. J Cell Biol 111: 2089-2096.
Schachner M (1991): Cell surface recognition and neuron-glia interactions. Ann N Y Acad Sci 633: 105-112.
Grumet M (1992): Structure, expression, and function of Ng-CAM, a member of the immunoglobulin superfamily involved in neuron-neuron and neuron-glia adhesion. J Neurosci Res 31: 1-13.
Pollerberg EG, Burridige K, Krebs AS, Goodman S, Schachner M (1987): The 180 kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions. Cell Tiss Res 250: 227-236.
Faissner A, Kruse J, Goridis C, Bock E, Schachner M (1984): The neural cell adhesion molecule LI is distinct from the N-CAM related group of surface antigens BSP-2 and D2. EMBO J 3: 733-737.
Lagenaur C, Lemmon V (1987): An LI-like molecule, the 8D9 antigen, is a potent substrate for neurite extension. Proc Natl Acad Sci USA 84: 7753-7757.
Simon H, Klinz S, Fahrig T, Schachner M (1991): Molecular association of the neural cell adhesion molecules LI and N-CAM in the surface membrane of neuroblastoma cells is shown by chemical crosslinking. Eur J Neurosci 3: 634-640.
Frei T, von Bohlen und Halbach F, Wille W, Schachner M (1992): Different extracellular domains of the neural cell adhesion molecule (N-CAM) are involved in different functions. J Cell Biol 118: 177-194.
Laemmli UK (1970): Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
Lemmon V, Farr KL, Lagenaur C (1989): LI-mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron 2: 1597-1603.
Goodman CS (1996): Mechanisms and molecules that control growth cone guidance. Annu Rev Neurosci 19: 341-377.
Werz W, Schachner M (1988): Adhesion of neural cells to extracellular constituents. Involvement of glycosaminoglycans and cell adhesion molecules. Dev Brain Res 43: 225-234.
Cremer H, Lange R, Christoph A, Plomann M, Vopper G, Roes J, Brown R, Baldwin S, Kraemer P, Scheff S, Barthels D, Rajewsky K, Wille W (1994): Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 367: 455-459.
Horstkorte R, Schachner M, Magyar JP, Vorherr T, Schmitz B (1993): The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with LI and neurite outgrowth. J Cell Biol 121: 1409-1421.
Small SJ, Haines SL, Akeson R (1988): Polypeptide variation in an NCAM extra-cellular immunoglobulin-like fold is developmentally regulated through alternative splicing. Neuron 1: 1007-1017.
Keilhauer G, Faissner A, Schachner M (1985): Differential inhibition of neuron-neuron, neuron-astrocyte, and astrocyte-astrocyte adhesion by LI, L2, and NCAM antibodies. Nature 316: 728-730.
Doherty P, Moolenaar CE, Ashton SV, Michalides RJ, Walsh FS (1992): The VASE exon downregulates the neurite growth-promoting activity of NCAM 140. Nature 356: 791-793.
Doherty P, Rowett LH, Moore SE, Mann DA, Walsh FS (1991): Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs. Neuron 6: 247-258.
Santoni MJ, Barthels D, Vopper G, Boned A, Goridis C, Wille W (1989): Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain. EMBO J 8: 385-392.
Guan KL, Dixon JE (1991): Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal Biochem 192: 262-267.
Saffell JL, Walsh FS, Doherty P (1994): Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum. J Cell Biol 125: 427-436.
Tessier-Lavigne M (1995): Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell 11: 345-348.
Beggs HE, Soriano P, Maness PF (1994): NCAM-dependent neurite outgrowth is inhibited in neurons from fyn-minus mice. J Cell Biol 127: 825-833.
Moos M, Tacke R, Scherer H, Teplow D, Früh K, Schachner M (1988): Neural adhesion molecule LI as a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Nature 334: 701-703.
Kadmon G, Kowitz A, Altevogt P, Schachner M (1990b) : Functional cooperation between the neural adhesion molecules LI and N-CAM is carbohydrate dependent. J Cell Biol 110: 209-218.
Walsh FS, Furness J, Moore SE, Ashton S, Doherty P (1992): Use of the neural cell adhesion molecule VASE exon by neurons is associated with a specific downregulation of neural cell adhesion dependent neurite outgrowth in the developing cerebellum and hippocampus. J Neurochem 59: 1959-1962.
Hoffman S, Edelman GM (1983): Kinetics of homophilic binding by E and A forms of the neural cell adhesion molecule. Proc Natl Acad Sci USA 80: 5762-5766.
Williams AF, Barclay AN (1988): The immunoglobulin superfamily domains for cell surface recognition. Annu Rev Immunol 6: 381-405.
Liu L, Haines S, Shew R, Akeson RA (1993): Axon growth is enhanced by NCAM lacking the VASE exon when expressed in either the growth substrate or the growing axon. J Neurosci Res 35: 327-345.
Rathjen FG, Schachner M (1984): Immunological and biochemical characterization of a new neuronal cell surface component (LI antigen) which is involved in cell adhesion. EMBO J 3: 1-10.
Ranheim TS, Edelman GM, Cunningham BA (1996): Homophilic adhesion mediated by the neural cell adhesion molecule involves multiple immunoglobulin domains. Proc Natl Acad Sci USA 93: 4071-4075.
Kadmon G, Kowitz A, Altevogt P, Schachner M (1990a) : The neural cell adhesion molecule N-CAM enhances LI-dependent cell-cell interactions. J Cell Biol 110: 193-208.
Rutishauser U, Edelman GM (1980): Effects of fasciculation on the outgrowth of neurites from spinal ganglia in culture. J Cell Biol 87: 370-378.
Doherty P, Walsh FS (1994): Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules. Curr Opin Neurobiol 4: 49-55.
Schwab ME (1990): Myelin-associated inhibitors of neurite growth and regeneration in the CNS. Trends Neurosci 13: 452-456.
Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N (1985): Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230: 1350-1354.
Towbin H, Staehelin T, Gordon J (1979): Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354.
Ignelzi MAJ, Miller DR, Soriano P, Maness PF (1994): Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule LI. Neuron 12: 873-884.
Yanish-Perron C, Vieira J, Messing J (1985): Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33: 103-119.
Barthels D, Santoni MJ, Wille W, Ruppert C, Chaix JC, Hirsch MR, Fontecilla-Champs JC, Goridis C (1987): Isolation and nucleotide sequence of mouse N-CAM cDNA that codes for a Mr 79000 polypeptide without a membrane-spanning region. EMBO J 6: 907-914.
Atashi JR, Klinz SG, Ingraham CA, Matten WT, Schachner M, Maness PF (1992): Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes. Neuron 8: 831-842.
Santoni MJ, Goridis C, Fontecilla-Camps JC (1988): Molecular modelling of the immunoglobulin-like domains of the neural cell adhesion molecule (NCAM): Implications for the positioning of functionally important sugar side chains. J Neurosci Res 20: 304-310.
Martini R, Schachner M (1986): Immunoelectron microscopic localization of neural cell adhesion molecules (LI, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. J Cell Biol 103: 2439-2448.
1989; 2
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1994; 367
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1988; 334
1988; 43
1992; 118
1978; 47
1983; 80
1985; 316
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1980
1985; 33
1990; 111
1994; 4
1985; 230
Lemmon (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB23) 1989; 2
Pollerberg (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB27) 1987; 250
Yanish-Perron (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB46) 1985; 33
Santoni (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB33) 1988; 20
Garnier (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB11) 1978; 120
Laemmli (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB21) 1970; 227
Simon (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB37) 1991; 3
Rutishauser (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB30) 1980; 87
Rathjen (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB29) 1984; 3
Chou (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB4) 1978; 47
Ranheim (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB28) 1996; 93
Walsh (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB43) 1992; 59
Doherty (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB8) 1991; 6
Faissner (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB9) 1984; 3
Atashi (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB1) 1992; 8
Ignelzi (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB17) 1994; 12
Keilhauer (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB20) 1985; 316
Doherty (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB7) 1992; 356
Werz (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB44) 1988; 43
Schachner (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB35) 1991; 633
Tessier-Lavigne (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB40) 1995; 11
Kadmon (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB18) 1990a; 110
Cremer (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB5) 1994; 367
Saiki (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB32) 1985; 230
Small (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB39) 1988; 1
Towbin (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB41) 1979; 76
Horstkorte (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB16) 1993; 121
Williams (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB45) 1988; 6
Guan (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB14) 1991; 192
Schwab (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB36) 1990; 13
Santoni (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB34) 1989; 8
Small (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB38) 1990; 111
Beggs (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB3) 1994; 127
Goodman (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB12) 1996; 19
Lagenaur (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB22) 1987; 84
Kadmon (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB19) 1990b; 110
Liu (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB24) 1993; 35
Hoffman (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB15) 1983; 80
Moos (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB26) 1988; 334
Doherty (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB6) 1994; 4
Frei (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB10) 1992; 118
Martini (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB25) 1986; 103
Saffell (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB31) 1994; 125
Barthels (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB2) 1987; 6
Grumet (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB13) 1992; 31
Voller (10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB42) 1980
References_xml – volume: 6
  start-page: 907
  year: 1987
  end-page: 914
  article-title: Isolation and nucleotide sequence of mouse N‐CAM cDNA that codes for a Mr 79000 polypeptide without a membrane‐spanning region
  publication-title: EMBO J
– volume: 31
  start-page: 1
  year: 1992
  end-page: 13
  article-title: Structure, expression, and function of Ng‐CAM, a member of the immunoglobulin superfamily involved in neuron‐neuron and neuron‐glia adhesion
  publication-title: J Neurosci Res
– volume: 316
  start-page: 728
  year: 1985
  end-page: 730
  article-title: Differential inhibition of neuron‐neuron, neuron‐astrocyte, and astrocyte‐astrocyte adhesion by LI, L2, and NCAM antibodies
  publication-title: Nature
– volume: 6
  start-page: 381
  year: 1988
  end-page: 405
  article-title: The immunoglobulin superfamily domains for cell surface recognition
  publication-title: Annu Rev Immunol
– volume: 20
  start-page: 304
  year: 1988
  end-page: 310
  article-title: Molecular modelling of the immunoglobulin‐like domains of the neural cell adhesion molecule (NCAM): Implications for the positioning of functionally important sugar side chains
  publication-title: J Neurosci Res
– volume: 19
  start-page: 341
  year: 1996
  end-page: 377
  article-title: Mechanisms and molecules that control growth cone guidance
  publication-title: Annu Rev Neurosci
– volume: 47
  start-page: 251
  year: 1978
  end-page: 276
  article-title: Empirical prediction of protein conformation
  publication-title: Annu Rev Biochem
– volume: 4
  start-page: 49
  year: 1994
  end-page: 55
  article-title: Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules
  publication-title: Curr Opin Neurobiol
– volume: 230
  start-page: 1350
  year: 1985
  end-page: 1354
  article-title: Enzymatic amplification of β‐globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia
  publication-title: Science
– volume: 3
  start-page: 634
  year: 1991
  end-page: 640
  article-title: Molecular association of the neural cell adhesion molecules LI and N‐CAM in the surface membrane of neuroblastoma cells is shown by chemical crosslinking
  publication-title: Eur J Neurosci
– volume: 80
  start-page: 5762
  year: 1983
  end-page: 5766
  article-title: Kinetics of homophilic binding by E and A forms of the neural cell adhesion molecule
  publication-title: Proc Natl Acad Sci USA
– volume: 111
  start-page: 2089
  year: 1990
  end-page: 2096
  article-title: Expression of the unique NCAM VASE exon is independently regulated in distinct tissues during development
  publication-title: J Cell Biol
– volume: 127
  start-page: 825
  year: 1994
  end-page: 833
  article-title: NCAM‐dependent neurite outgrowth is inhibited in neurons from fyn‐minus mice
  publication-title: J Cell Biol
– volume: 192
  start-page: 262
  year: 1991
  end-page: 267
  article-title: Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S‐transferase
  publication-title: Anal Biochem
– volume: 8
  start-page: 831
  year: 1992
  end-page: 842
  article-title: Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes
  publication-title: Neuron
– volume: 3
  start-page: 733
  year: 1984
  end-page: 737
  article-title: The neural cell adhesion molecule LI is distinct from the N‐CAM related group of surface antigens BSP‐2 and D2
  publication-title: EMBO J
– volume: 12
  start-page: 873
  year: 1994
  end-page: 884
  article-title: Impaired neurite outgrowth of src‐minus cerebellar neurons on the cell adhesion molecule LI
  publication-title: Neuron
– volume: 93
  start-page: 4071
  year: 1996
  end-page: 4075
  article-title: Homophilic adhesion mediated by the neural cell adhesion molecule involves multiple immunoglobulin domains
  publication-title: Proc Natl Acad Sci USA
– volume: 13
  start-page: 452
  year: 1990
  end-page: 456
  article-title: Myelin‐associated inhibitors of neurite growth and regeneration in the CNS
  publication-title: Trends Neurosci
– volume: 2
  start-page: 1597
  year: 1989
  end-page: 1603
  article-title: LI‐mediated axon outgrowth occurs via a homophilic binding mechanism
  publication-title: Neuron
– volume: 118
  start-page: 177
  year: 1992
  end-page: 194
  article-title: Different extracellular domains of the neural cell adhesion molecule (N‐CAM) are involved in different functions
  publication-title: J Cell Biol
– volume: 76
  start-page: 4350
  year: 1979
  end-page: 4354
  article-title: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
  publication-title: Proc Natl Acad Sci USA
– volume: 6
  start-page: 247
  year: 1991
  end-page: 258
  article-title: Neurite outgrowth in response to transfected N‐CAM and N‐cadherin reveals fundamental differences in neuronal responsiveness to CAMs
  publication-title: Neuron
– volume: 121
  start-page: 1409
  year: 1993
  end-page: 1421
  article-title: The fourth immunoglobulin‐like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with LI and neurite outgrowth
  publication-title: J Cell Biol
– volume: 110
  start-page: 193
  year: 1990a
  end-page: 208
  article-title: : The neural cell adhesion molecule N‐CAM enhances LI‐dependent cell‐cell interactions
  publication-title: J Cell Biol
– volume: 120
  start-page: 97
  year: 1978
  end-page: 120
  article-title: Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins
  publication-title: J Mol Biol
– volume: 84
  start-page: 7753
  year: 1987
  end-page: 7757
  article-title: An LI‐like molecule, the 8D9 antigen, is a potent substrate for neurite extension
  publication-title: Proc Natl Acad Sci USA
– volume: 103
  start-page: 2439
  year: 1986
  end-page: 2448
  article-title: Immunoelectron microscopic localization of neural cell adhesion molecules (LI, N‐CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve
  publication-title: J Cell Biol
– volume: 250
  start-page: 227
  year: 1987
  end-page: 236
  article-title: The 180 kD component of the neural cell adhesion molecule N‐CAM is involved in cell‐cell contacts and cytoskeleton‐membrane interactions
  publication-title: Cell Tiss Res
– volume: 3
  start-page: 1
  year: 1984
  end-page: 10
  article-title: Immunological and biochemical characterization of a new neuronal cell surface component (LI antigen) which is involved in cell adhesion
  publication-title: EMBO J
– volume: 110
  start-page: 209
  year: 1990b
  end-page: 218
  article-title: : Functional cooperation between the neural adhesion molecules LI and N‐CAM is carbohydrate dependent
  publication-title: J Cell Biol
– volume: 334
  start-page: 701
  year: 1988
  end-page: 703
  article-title: Neural adhesion molecule LI as a member of the immunoglobulin superfamily with binding domains similar to fibronectin
  publication-title: Nature
– volume: 8
  start-page: 385
  year: 1989
  end-page: 392
  article-title: Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brain
  publication-title: EMBO J
– volume: 367
  start-page: 455
  year: 1994
  end-page: 459
  article-title: Inactivation of the N‐CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning
  publication-title: Nature
– volume: 1
  start-page: 1007
  year: 1988
  end-page: 1017
  article-title: Polypeptide variation in an NCAM extra‐cellular immunoglobulin‐like fold is developmentally regulated through alternative splicing
  publication-title: Neuron
– volume: 33
  start-page: 103
  year: 1985
  end-page: 119
  article-title: Improved M13 phage cloning vectors and host strains: Nucleotide sequences of the M13mp18 and pUC19 vectors
  publication-title: Gene
– volume: 633
  start-page: 105
  year: 1991
  end-page: 112
  article-title: Cell surface recognition and neuron‐glia interactions
  publication-title: Ann N Y Acad Sci
– volume: 11
  start-page: 345
  year: 1995
  end-page: 348
  article-title: Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps
  publication-title: Cell
– start-page: 359
  year: 1980
  end-page: 371
– volume: 35
  start-page: 327
  year: 1993
  end-page: 345
  article-title: Axon growth is enhanced by NCAM lacking the VASE exon when expressed in either the growth substrate or the growing axon
  publication-title: J Neurosci Res
– volume: 356
  start-page: 791
  year: 1992
  end-page: 793
  article-title: The VASE exon downregulates the neurite growth‐promoting activity of NCAM 140
  publication-title: Nature
– volume: 87
  start-page: 370
  year: 1980
  end-page: 378
  article-title: Effects of fasciculation on the outgrowth of neurites from spinal ganglia in culture
  publication-title: J Cell Biol
– volume: 125
  start-page: 427
  year: 1994
  end-page: 436
  article-title: Expression of NCAM containing VASE in neurons can account for a developmental loss in their neurite outgrowth response to NCAM in a cellular substratum
  publication-title: J Cell Biol
– volume: 43
  start-page: 225
  year: 1988
  end-page: 234
  article-title: Adhesion of neural cells to extracellular constituents. Involvement of glycosaminoglycans and cell adhesion molecules
  publication-title: Dev Brain Res
– volume: 227
  start-page: 680
  year: 1970
  end-page: 685
  article-title: Cleavage of structural proteins during the assembly of the head of bacteriophage T4
  publication-title: Nature
– volume: 59
  start-page: 1959
  year: 1992
  end-page: 1962
  article-title: Use of the neural cell adhesion molecule VASE exon by neurons is associated with a specific downregulation of neural cell adhesion dependent neurite outgrowth in the developing cerebellum and hippocampus
  publication-title: J Neurochem
– volume: 35
  start-page: 327
  year: 1993
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB24
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.490350313
  contributor:
    fullname: Liu
– volume: 230
  start-page: 1350
  year: 1985
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB32
  publication-title: Science
  doi: 10.1126/science.2999980
  contributor:
    fullname: Saiki
– volume: 127
  start-page: 825
  year: 1994
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB3
  publication-title: J Cell Biol
  doi: 10.1083/jcb.127.3.825
  contributor:
    fullname: Beggs
– volume: 3
  start-page: 634
  year: 1991
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB37
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.1991.tb00849.x
  contributor:
    fullname: Simon
– volume: 43
  start-page: 225
  year: 1988
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB44
  publication-title: Dev Brain Res
  doi: 10.1016/0165-3806(88)90101-0
  contributor:
    fullname: Werz
– volume: 76
  start-page: 4350
  year: 1979
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB41
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.76.9.4350
  contributor:
    fullname: Towbin
– volume: 227
  start-page: 680
  year: 1970
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB21
  publication-title: Nature
  doi: 10.1038/227680a0
  contributor:
    fullname: Laemmli
– volume: 87
  start-page: 370
  year: 1980
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB30
  publication-title: J Cell Biol
  doi: 10.1083/jcb.87.2.370
  contributor:
    fullname: Rutishauser
– volume: 121
  start-page: 1409
  year: 1993
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB16
  publication-title: J Cell Biol
  doi: 10.1083/jcb.121.6.1409
  contributor:
    fullname: Horstkorte
– volume: 118
  start-page: 177
  year: 1992
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB10
  publication-title: J Cell Biol
  doi: 10.1083/jcb.118.1.177
  contributor:
    fullname: Frei
– volume: 8
  start-page: 385
  year: 1989
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB34
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1989.tb03389.x
  contributor:
    fullname: Santoni
– volume: 1
  start-page: 1007
  year: 1988
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB39
  publication-title: Neuron
  doi: 10.1016/0896-6273(88)90158-4
  contributor:
    fullname: Small
– volume: 11
  start-page: 345
  year: 1995
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB40
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90421-2
  contributor:
    fullname: Tessier-Lavigne
– volume: 59
  start-page: 1959
  year: 1992
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB43
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.1992.tb11033.x
  contributor:
    fullname: Walsh
– volume: 12
  start-page: 873
  year: 1994
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB17
  publication-title: Neuron
  doi: 10.1016/0896-6273(94)90339-5
  contributor:
    fullname: Ignelzi
– volume: 6
  start-page: 381
  year: 1988
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB45
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev.iy.06.040188.002121
  contributor:
    fullname: Williams
– volume: 125
  start-page: 427
  year: 1994
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB31
  publication-title: J Cell Biol
  doi: 10.1083/jcb.125.2.427
  contributor:
    fullname: Saffell
– volume: 110
  start-page: 193
  year: 1990a
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB18
  publication-title: J Cell Biol
  doi: 10.1083/jcb.110.1.193
  contributor:
    fullname: Kadmon
– volume: 3
  start-page: 1
  year: 1984
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB29
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1984.tb01753.x
  contributor:
    fullname: Rathjen
– start-page: 359
  volume-title: Manual of Clinical Immunology
  year: 1980
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB42
  contributor:
    fullname: Voller
– volume: 120
  start-page: 97
  year: 1978
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB11
  publication-title: J Mol Biol
  doi: 10.1016/0022-2836(78)90297-8
  contributor:
    fullname: Garnier
– volume: 80
  start-page: 5762
  year: 1983
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB15
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.80.18.5762
  contributor:
    fullname: Hoffman
– volume: 13
  start-page: 452
  year: 1990
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB36
  publication-title: Trends Neurosci
  doi: 10.1016/0166-2236(90)90098-U
  contributor:
    fullname: Schwab
– volume: 19
  start-page: 341
  year: 1996
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB12
  publication-title: Annu Rev Neurosci
  doi: 10.1146/annurev.ne.19.030196.002013
  contributor:
    fullname: Goodman
– volume: 334
  start-page: 701
  year: 1988
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB26
  publication-title: Nature
  doi: 10.1038/334701a0
  contributor:
    fullname: Moos
– volume: 4
  start-page: 49
  year: 1994
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB6
  publication-title: Curr Opin Neurobiol
  doi: 10.1016/0959-4388(94)90031-0
  contributor:
    fullname: Doherty
– volume: 250
  start-page: 227
  year: 1987
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB27
  publication-title: Cell Tiss Res
  doi: 10.1007/BF00214676
  contributor:
    fullname: Pollerberg
– volume: 8
  start-page: 831
  year: 1992
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB1
  publication-title: Neuron
  doi: 10.1016/0896-6273(92)90197-L
  contributor:
    fullname: Atashi
– volume: 31
  start-page: 1
  year: 1992
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB13
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.490310102
  contributor:
    fullname: Grumet
– volume: 192
  start-page: 262
  year: 1991
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB14
  publication-title: Anal Biochem
  doi: 10.1016/0003-2697(91)90534-Z
  contributor:
    fullname: Guan
– volume: 356
  start-page: 791
  year: 1992
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB7
  publication-title: Nature
  doi: 10.1038/356791a0
  contributor:
    fullname: Doherty
– volume: 3
  start-page: 733
  year: 1984
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB9
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1984.tb01876.x
  contributor:
    fullname: Faissner
– volume: 316
  start-page: 728
  year: 1985
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB20
  publication-title: Nature
  doi: 10.1038/316728a0
  contributor:
    fullname: Keilhauer
– volume: 84
  start-page: 7753
  year: 1987
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB22
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.84.21.7753
  contributor:
    fullname: Lagenaur
– volume: 93
  start-page: 4071
  year: 1996
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB28
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.93.9.4071
  contributor:
    fullname: Ranheim
– volume: 20
  start-page: 304
  year: 1988
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB33
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.490200304
  contributor:
    fullname: Santoni
– volume: 33
  start-page: 103
  year: 1985
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB46
  publication-title: Gene
  doi: 10.1016/0378-1119(85)90120-9
  contributor:
    fullname: Yanish-Perron
– volume: 2
  start-page: 1597
  year: 1989
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB23
  publication-title: Neuron
  doi: 10.1016/0896-6273(89)90048-2
  contributor:
    fullname: Lemmon
– volume: 111
  start-page: 2089
  year: 1990
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB38
  publication-title: J Cell Biol
  doi: 10.1083/jcb.111.5.2089
  contributor:
    fullname: Small
– volume: 47
  start-page: 251
  year: 1978
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB4
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.bi.47.070178.001343
  contributor:
    fullname: Chou
– volume: 367
  start-page: 455
  year: 1994
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB5
  publication-title: Nature
  doi: 10.1038/367455a0
  contributor:
    fullname: Cremer
– volume: 103
  start-page: 2439
  year: 1986
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB25
  publication-title: J Cell Biol
  doi: 10.1083/jcb.103.6.2439
  contributor:
    fullname: Martini
– volume: 6
  start-page: 247
  year: 1991
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB8
  publication-title: Neuron
  doi: 10.1016/0896-6273(91)90360-C
  contributor:
    fullname: Doherty
– volume: 633
  start-page: 105
  year: 1991
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB35
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.1991.tb15601.x
  contributor:
    fullname: Schachner
– volume: 6
  start-page: 907
  year: 1987
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB2
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1987.tb04837.x
  contributor:
    fullname: Barthels
– volume: 110
  start-page: 209
  year: 1990b
  ident: 10.1002/(SICI)1097-4547(19971001)50:1<62::AID-JNR7>3.0.CO;2-J-BIB19
  publication-title: J Cell Biol
  doi: 10.1083/jcb.110.1.209
  contributor:
    fullname: Kadmon
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Snippet Interactions between the neural cell adhesion molecule (NCAM) with NCAM‐expressing neurons (trans‐interaction) stimulate outgrowth of neurites. The extent of...
Interactions between the neural cell adhesion molecule (NCAM) with NCAM-expressing neurons (trans-interaction) stimulate outgrowth of neurites. The extent of...
Interactions between the neural cell adhesion molecule (NCAM) with NCAM-expressing neurons (transinteraction) stimulate outgrowth of neurites. The extent of...
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StartPage 62
SubjectTerms Alternative Splicing - physiology
Animals
Cell Adhesion Molecules, Neuronal - chemistry
Cell Adhesion Molecules, Neuronal - metabolism
Cells, Cultured
Cerebellum - cytology
Cloning, Molecular
Exons - genetics
Gene Expression - physiology
Immunoglobulins - chemistry
Leukocyte L1 Antigen Complex
Membrane Glycoproteins - metabolism
Mice
Mice, Mutant Strains
NCAM
neurite outgrowth
Neurites - chemistry
Neurites - drug effects
Neurites - physiology
Oligopeptides - genetics
Recombinant Proteins
VASE
π-exon
Title VASE-encoded peptide modifies NCAM- and L1-mediated neurite outgrowth
URI https://api.istex.fr/ark:/67375/WNG-X3PML3Z8-6/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2F%28SICI%291097-4547%2819971001%2950%3A1%3C62%3A%3AAID-JNR7%3E3.0.CO%3B2-J
https://www.ncbi.nlm.nih.gov/pubmed/9379494
https://search.proquest.com/docview/16299383
https://search.proquest.com/docview/79383439
Volume 50
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