Tecovirimat is active against various MPXV strains, while cidofovir, brincidofovir, trifluridine, and gemcitabine have no detectable MPXV-specific antiviral activity

• Published in: Virus research Vol. 360; p. 199615
• Main Authors: Higashi-Kuwata, Nobuyo, Kato, Mariko, Hattori, Shin-ichiro, Takamatsu, Yuki, Mitsuya, Hiroaki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2025; Elsevier
• Subjects: antiviral agents; antiviral assays; morphometric assays; Mpox; tecovirimat-resistant MPXV; antiviral assays; morphometric assays; Mpox; antiviral agents; tecovirimat-resistant MPXV

•Compounds reportedly active against MPXVs are in controversy and are revisited.•Only tecovirimat among agents tested here exhibits MPXV-specific antiviral activity.•Apparent anti-MPXV activity of agents except tecovirimat results from their toxicity.•Novel agents more potent than tecovirimat are ur...