Conditional neuronal deletion of microRNA ‐141/200c cluster, but not microRNA ‐181a/b‐1 cluster, is protective against experimental stroke in male mice

• Published in: Physiological reports Vol. 13; no. 15; pp. e70505 - n/a
• Main Authors: Xu, Lijun, Griffiths, Brian, Sun, Xiaoyun, Greer, Majesty, Chang, Heather, McMillin, Elijah, Manis, Elizabeth, Russo, Isabella, Dean, Claire Ai Jue, Stary, Creed M.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2025; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Brain; Ca2+/calmodulin-dependent protein kinase; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Calmodulin; Carotid arteries; cell type; Cerebral blood flow; CKIIα; Gene Deletion; Hybridization; Immunohistochemistry; Infarction, Middle Cerebral Artery - genetics; Infarction, Middle Cerebral Artery - metabolism; Ischemia; Kinases; Male; MCAO; Mice; Mice, Transgenic; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miR; miRNA; Neurons - metabolism; Original; Pharmaceuticals; Recombinase; Regular Manuscript; Statistical analysis; Stroke; Stroke - genetics; Stroke - metabolism; Tamoxifen; Transgenic animals; Transgenic mice; Veins & arteries; MCAO; miRNA; CKIIα; cell type; miR

MicroRNAs (miRs) regulate the translation of target genes often in a cell‐type specific manner. We previously demonstrated that downregulation of either miR‐181a or miR‐200c with intracranial injection of an inhibitor is protective against experimental stroke in mice. Here, we generated genetic line...