Spot 14: A Marker of Aggressive Breast Cancer and a Potential Therapeutic Target

• Published in: Endocrinology (Philadelphia) Vol. 147; no. 9; pp. 4048 - 4055
• Main Authors: Kinlaw, William B, Quinn, Jennifer L, Wells, Wendy A, Roser-Jones, Christopher, Moncur, Joel T
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.09.2006; Oxford University Press
• Subjects: Animal fat; Animals; Antagonists; Apoptosis; Biomarkers, Tumor; Breast cancer; Breast milk; Breast Neoplasms - chemistry; Breast Neoplasms - genetics; Breast Neoplasms - therapy; Cell proliferation; DNA, Complementary - genetics; Female; Hormones; Humans; Lipids; Lipids - biosynthesis; Lipogenesis; Lipoprotein lipase; Lymph nodes; Mammary gland; Mammary glands; Metastases; Mice; Nuclear fuels; Nuclear Proteins - analysis; Nuclear Proteins - genetics; Nuclear Proteins - physiology; Oligonucleotide Array Sequence Analysis; Progestin; Protein biosynthesis; Synthesis; Target spot; Therapeutic targets; Transcription Factors - analysis; Transcription Factors - genetics; Transcription Factors - physiology

Spot 14 (S14) is a nuclear protein that communicates the status of dietary fuels and fuel-related hormones to genes required for long-chain fatty acid synthesis. In mammary gland, S14 is important for both epithelial proliferation and milk fat production. The S14 gene is amplified in some breast can...