Novel Neuromodulation Approach to Improve Left Ventricular Contractility in Heart Failure: A First-in-Human Proof-of-Concept Study

• Published in: Circulation. Arrhythmia and electrophysiology Vol. 13; no. 11; p. e008407
• Main Authors: Y. Reddy, Vivek, Petrů, Jan, Málek, Filip, Stylos, Lee, Goedeke, Steve, Neužil, Petr
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.11.2020
• Subjects: Aged; Autonomic Nervous System - physiopathology; Cardiac Pacing, Artificial - adverse effects; Cardiac Pacing, Artificial - methods; Female; Heart - innervation; Heart Failure - diagnosis; Heart Failure - physiopathology; Heart Failure - therapy; Humans; Male; Middle Aged; Myocardial Contraction; Proof of Concept Study; Recovery of Function; Time Factors; Treatment Outcome; Ventricular Function, Left; blood pressure; heart failure; arterial pressure; heart rate; pulmonary artery

Morbidity and mortality outcomes for patients admitted for acute decompensated heart failure are poor and have not significantly changed in decades. Current therapies are focused on symptom relief by addressing signs and symptoms of congestion. The objective of this study was to test a novel neuromo...