Testing for Nondisjunction in the Mouse

• Published in: Environmental health perspectives Vol. 31; pp. 123 - 129
• Main Authors: Chandley, Ann C., Speed, R. M.
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01.08.1979
• Subjects: Abnormalities, Radiation-Induced - genetics; Aneuploidy; Animals; Chromosome Aberrations - chemically induced; Chromosome Aberrations - genetics; Chromosome Disorders; Chromosomes; Embryos; Female; Fetus; Genetic Techniques; Germ cells; Gestational Age; Irradiation; Karyotype; Male; Mice; Mitomycins - toxicity; Mosaicism; Spermatocytes; Spermatogonia; Spermatozoa - drug effects; Spermatozoa - radiation effects; Systems to Detect the Induction of Aneuploidy by Environmental Mutagens. Savannah, Georgia, November 5-8, 1978; Trisomics; Trisomy; X-Rays

Tests for nondisjunction have been carried out in male and female mice. Ten-day fetal progeny of control and treated adults have been karyotyped to establish spontaneous and induced levels of aneuploidy. In males, the effects of 100 rad x-rays on type A spermatogonia and early primary spermatocytes,...