Tumor necrosis factor α1 decreases mucosal immune and antioxidant response in the midgut of hybrid fish (white crucian carp ♀ × red crucian carp ♂)

• Published in: Journal of fish biology Vol. 104; no. 6; pp. 1899 - 1909
• Main Authors: Li, Ke‐Xin, Xiong, Ning‐Xia, Huang, Jin‐Fang, Li, Shi‐Yun, Ou, Jie, Wang, Fei, Luo, Sheng‐Wei
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2024; Wiley Subscription Services, Inc
• Subjects: absorption barrier; Animals; antioxidant activity; Antioxidants; Antioxidants - metabolism; Apoptosis; Atrophy; Carassius auratus; Carassius cuvieri; Carp; Carps - genetics; Carps - immunology; Carps - metabolism; crucian carp; Cultured organisms; Digestive system; farmed fish; Female; Fish; Fish culture; Fish Proteins - genetics; Fish Proteins - metabolism; Freshwater fishes; Gastrointestinal tract; Gene expression; Genes; Homeostasis; Hybridization, Genetic; immune regulation; Immunity, Mucosal; immunomodulation; Immunoregulation; Intestine; intestines; Male; Midgut; Mucin; mucins; Mucosal immunity; Necrosis; Neoplasms; TNFα1; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; tumor necrosis factors; White; TNFα1; crucian carp; gene expression; immune regulation

Tumor necrosis factor α1 (TNFα) is a pleiotropic cytokine involved in immune regulation and cellular homeostasis, but the crucial role of TNFα in fish gut remained unclear. The current study aimed to evaluate the immunoregulatory function of TNFα1 on gut barrier in a novel hybrid fish (WR), which wa...