Participation of high glucose concentrations in neutrophil adhesion and surface expression of adhesion molecules on cultured human endothelial cells: Effect of antidiabetic medicines

• Published in: Journal of diabetes and its complications Vol. 16; no. 3; pp. 201 - 208
• Main Authors: Omi, Hitoshi, Okayama, Naotsuka, Shimizu, Manabu, Okouchi, Masahiro, Ito, Shigenori, Fukutomi, Tatsuya, Itoh, Makoto
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2002; Elsevier Science
• Subjects: Aldose reductase inhibitor; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Carbazoles - pharmacology; Cardiology. Vascular system; Cell Adhesion - physiology; Cells, Cultured; E-selectin; E-Selectin - metabolism; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Enzyme Inhibitors - pharmacology; Glucose - pharmacology; Heart; Humans; Hypoglycemic Agents - pharmacology; Indoles - pharmacology; Intercellular adhesion molecule-1; Intercellular Adhesion Molecule-1 - metabolism; Medical sciences; Myocarditis. Cardiomyopathies; Neutrophils - physiology; P-selectin; P-Selectin - metabolism; Peroxidase - metabolism; Protein Kinase C - antagonists & inhibitors; Sulfonylurea; Umbilical Veins; Aldose reductase inhibitor; E-selectin; Sulfonylurea; P-selectin; Intercellular adhesion molecule-1; Endocrinopathy; Cell culture; Epalrestat; Glimepiride; Participation; Endothelial cell; Cardiovascular disease; Glucose; Myocardial disease; Vascular disease; Molecules; Hyperglycemia; Heart disease; Atherosclerosis; Glibenclamide; Cerebrovascular disease; Human; Nervous system diseases; Stroke; Diabetes mellitus; Inflammation; Concentration; Gene expression; Enzyme immunoassay; Adhesion; Cerebral disorder; Medicine; Central nervous system disease; Gliclazide; Neutrophil; Troglitazone

Background: Atherosclerosis and vascular inflammation induced by hyperglycemia are important factors in the promotion of diabetic complications. One of the earliest events in the inflammatory process is increased binding of neutrophils to endothelial cells. Since vascular inflammation has been recen...