Postnatal ovary development in the rat: morphologic study and correlation of morphology to neuroendocrine parameters

• Published in: Toxicologic pathology Vol. 43; no. 3; p. 343
• Main Authors: Picut, Catherine A, Dixon, Darlene, Simons, Michelle L, Stump, Donald G, Parker, George A, Remick, Amera K
• Format: Journal Article
• Language: English
• Published: United States 01.04.2015
• Subjects: Aging - physiology; Animals; Animals, Newborn; Estrus - physiology; Female; Gonadal Steroid Hormones - blood; Neurosecretory Systems - growth & development; Neurosecretory Systems - physiology; Ovarian Follicle - physiology; Ovary - anatomy & histology; Ovary - growth & development; Ovary - physiology; Rats; Rats, Sprague-Dawley; Sprague-Dawley rats; ovary; endocrine disruptors; pubertal assay; female; postnatal development; reproduction

Histopathologic examination of the immature ovary is a required end point on juvenile toxicity studies and female pubertal and thyroid function assays. To aid in this evaluation and interpretation of the immature ovary, the characteristic histologic features of rat ovary through the developmental pe...