Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations

A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents additio...

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Published inJournal of the Brazilian Chemical Society Vol. 20; no. 9; pp. 1646 - 1652
Main Authors Chagas, Manoel P., Santos, Josué C. C., Santos, Eduardo B. G. N., Oliveira, Tiago D., Korn, Mauro
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 2009
Subjects
CHEMISTRY, MULTIDISCIPLINARY
flow injection analysis
iminoquinone radical reaction
determination of thiol drugs
Captopril
N-acetyl-L-cysteine
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Abstract A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L-1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L-1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. The procedure was employed for CPT and NAC determination in diverse pharmaceutical formulations and by applying paired t-test the results were in agreement with those obtained by reference methods for 95% confidence level.
AbstractList A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on the reaction with iminoquinone radical produced from the N,N-dimethyl-p-phenilenediamene (DMPD) oxidation in acid medium. The reagents addition order was evaluated and analytical parameters were optimized. The linear concentrations ranges were 2.5-90 and 5.0-50 mg L-1 for CPT and NAC, respectively. Limits of detection (3σ) were calculated at 0.22 and 1.8 mg L-1 and the relative standard deviation (N = 10) were lower than 1.0 and 2.1% for CPT and NAC, respectively. The procedure was employed for CPT and NAC determination in diverse pharmaceutical formulations and by applying paired t-test the results were in agreement with those obtained by reference methods for 95% confidence level.
Author Korn, Mauro
Chagas, Manoel P.
Santos, Eduardo B. G. N.
Santos, Josué C. C.
Oliveira, Tiago D.
AuthorAffiliation Universidade do Estado da Bahia
Universidade Federal da Bahia
União Metropolitana de Educação e Cultura
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Issue 9
Keywords flow injection analysis
iminoquinone radical reaction
determination of thiol drugs
Captopril
N-acetyl-L-cysteine
Language English
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Snippet A spectrophotometric flow analysis procedure to determine Captopril (CPT) and N-acetyl-L-cysteine (NAC) in pharmaceutical formulations was developed based on...
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SubjectTerms CHEMISTRY, MULTIDISCIPLINARY
Title Exploiting iminoquinone free radical production for thiol based drugs determination in pharmaceutical formulations
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