Comparison of β-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: amorphic plaques and cytoskeletal changes occur independently

• Published in: Acta neuropathologica Vol. 96; no. 2; pp. 129 - 138
• Main Authors: van de Nes, J. A. P., Kamphorst, W., Ravid, R., Swaab, D. F.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.08.1998; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid; Amyloid beta-Peptides - metabolism; Antigens - metabolism; Biological and medical sciences; Brain; Coloring Agents; Cytoskeleton; Cytoskeleton - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia disorders; Female; Humans; Hypothalamus; Hypothalamus - metabolism; Hypothalamus - pathology; Hypotheses; Male; Medical sciences; Middle Aged; Nerve Tissue Proteins - metabolism; Neurodegenerative diseases; Neurology; Plaque, Amyloid - pathology; Senile plaques; Human; Immunohistochemistry; Nervous system diseases; Senile plate; Alzheimer disease; Hypothalamus; Cerebral disorder; Case study; Pathology; β Amyloid protein; Central nervous system disease; Cytoskeleton; Degenerative disease; Elderly; Deposition; Comparative study

Alzheimer's disease is characterized neuropathologically by senile plaques and cytoskeletal changes. It has been proposed that amorphic plaques would locally induce anterograde propagation of cytoskeletal changes in consecutive neurons followed by amorphic plaque deposition at their axonal term...