Epithelial–Mesenchymal Transitioned Circulating Tumor Cells Capture for Detecting Tumor Progression

• Published in: Clinical cancer research Vol. 21; no. 4; pp. 899 - 906
• Main Authors: Satelli, Arun, Mitra, Abhisek, Brownlee, Zachary, Xia, Xueqing, Bellister, Seth, Overman, Michael J., Kopetz, Scott, Ellis, Lee M., Meng, Qing H., Li, Shulin
• Format: Journal Article
• Language: English
• Published: United States 15.02.2015
• Subjects: Adult; Aged; Antibodies, Monoclonal; Biomarkers, Tumor - analysis; Colonic Neoplasms - diagnosis; Disease Progression; Epithelial-Mesenchymal Transition; Female; Flow Cytometry; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Neoplastic Cells, Circulating; Sensitivity and Specificity; Single-Cell Analysis; Vimentin - analysis; Vimentin - biosynthesis

Purpose: This study aimed to detect cell-surface vimentin (CSV) on the surface of epithelial–mesenchymal transitioned (EMT) circulating tumor cells (CTC) from blood of patients with epithelial cancers. Experimental Design: In this study, 101 patients undergoing postsurgery adjuvant chemotherapy for...