Insight into Recent Drug Discoveries against Trypanosomatids and Plasmodium spp Parasites: New Metal-based Compounds

Scaffolds of metal-based compounds can act as pharmacophore groups in several ligands to treat various diseases, including tropical infectious diseases (TID). In this review article, we investigate the contribution of these moieties to medicinal inorganic chemistry in the last seven years against TI...

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Bibliographic Details
Published inCurrent medicinal chemistry Vol. 29; no. 13; p. 2334
Main Authors Scarim, Cauê Benito, de Farias, Renan Lira, Chiba, Diego Eidy, Chin, Chung Man
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.04.2022
Subjects
Animals
Chagas Disease - drug therapy
Drug Discovery
Humans
Parasites
Plasmodium
Trypanosoma cruzi
Trypanosomiasis, African - drug therapy
Metal-based drugs
T. brucei
T. cruzi
Plasmodium ssp
Leishmania
new drugs
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Summary:Scaffolds of metal-based compounds can act as pharmacophore groups in several ligands to treat various diseases, including tropical infectious diseases (TID). In this review article, we investigate the contribution of these moieties to medicinal inorganic chemistry in the last seven years against TID, including American trypanosomiasis (Chagas disease), human African trypanosomiasis (HAT, sleeping sickness), leishmania, and malaria. The most potent metal-based complexes are displayed and highlighted in figures, tables and graphics; according to their pharmacological activities (IC > 10μM) against Trypanosomatids and Plasmodium spp parasites. We highlight the current progresses and viewpoints of these metal-based complexes, with a specific focus on drug discovery.
ISSN:1875-533X
DOI:10.2174/0929867328666210917114912