Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care

• Published in: Learning & memory (Cold Spring Harbor, N.Y.) Vol. 28; no. 9; pp. 341 - 347
• Main Authors: Fulton, Sasha L., Hsieh, Changchi, Atkin, Tobias, Norris, Ryan, Schoenfeld, Eric, Tsokas, Panayiotis, Fenton, André Antonio, Sacktor, Todd Charlton, Coplan, Jeremy D.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.09.2021
• Subjects: Animals; Anxiety disorders; Dentate gyrus; Emotions; Hippocampus; Hippocampus - metabolism; Immunohistochemistry; Kinases; Long term memory; Long-Term Potentiation; Macaca radiata; Male; Protein kinase; Protein Kinase C - metabolism; Stress, Psychological; Subiculum

Protein kinase Mζ (PKMζ) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is a precursor to adult mood and anxiety disorders, in part, through persistent disruption of emotional memory throughout life. Here we subject...