Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
Abstract The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude h...
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Published in | Brazilian Journal of Pharmaceutical Sciences Vol. 58 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2022
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Abstract | Abstract The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions. |
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AbstractList | Abstract The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions. |
Author | Nakamura, Celso Vataru Ferreira, Lilian dos Anjos Oliveira Mello, João Carlos Palazzo de Castro-Hoshino, Lidiane Vizioli de Truiti, Maria da Conceição Torrado Nocchi, Samara Requena Dias Filho, Benedito Prado Baesso, Mauro Luciano Natali, Maria Raquel Marçal Ueda-Nakamura, Tânia |
AuthorAffiliation | Universidade Estadual de Maringá |
AuthorAffiliation_xml | – sequence: 0 name: Universidade Estadual de Maringá |
Author_xml | – sequence: 1 givenname: Samara Requena surname: Nocchi fullname: Nocchi, Samara Requena organization: Universidade Estadual de Maringá, Brazil – sequence: 2 givenname: Lilian dos Anjos Oliveira surname: Ferreira fullname: Ferreira, Lilian dos Anjos Oliveira organization: Universidade Estadual de Maringá, Brazil – sequence: 3 givenname: Lidiane Vizioli de surname: Castro-Hoshino fullname: Castro-Hoshino, Lidiane Vizioli de organization: Universidade Estadual de Maringá, Brazil – sequence: 4 givenname: Maria da Conceição Torrado surname: Truiti fullname: Truiti, Maria da Conceição Torrado organization: Universidade Estadual de Maringá, Brazil – sequence: 5 givenname: Maria Raquel Marçal surname: Natali fullname: Natali, Maria Raquel Marçal organization: Universidade Estadual de Maringá, Brazil – sequence: 6 givenname: João Carlos Palazzo de surname: Mello fullname: Mello, João Carlos Palazzo de organization: Universidade Estadual de Maringá, Brazil – sequence: 7 givenname: Mauro Luciano surname: Baesso fullname: Baesso, Mauro Luciano organization: Universidade Estadual de Maringá, Brazil – sequence: 8 givenname: Benedito Prado surname: Dias Filho fullname: Dias Filho, Benedito Prado organization: Universidade Estadual de Maringá, Brazil – sequence: 9 givenname: Celso Vataru surname: Nakamura fullname: Nakamura, Celso Vataru organization: Universidade Estadual de Maringá, Brazil – sequence: 10 givenname: Tânia orcidid: 0000-0001-5057-3518 surname: Ueda-Nakamura fullname: Ueda-Nakamura, Tânia organization: Universidade Estadual de Maringá, Brazil |
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Cites_doi | 10.1016/j.antiviral.2008.05.002 10.1016/j.jaad.2007.06.027 10.4034/1519.0501.2007.0073.0010 10.1155/2017/1416375 10.1016/0166-3542(94)00076-K 10.1111/j.1600-0714.2007.00586.x 10.1016/j.intimp.2008.06.012 10.4103/0973-1296.177903 10.1016/S0166-3542(03)00152-9 10.3109/13880209.2015.1021817 10.1056/NEJM197707142970201 10.1016/j.jcv.2011.08.003 10.1016/j.jcv.2004.02.009 |
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Keywords | Photoacoustic Skin irritation HSV-1 Topical formulations In vivo efficacy Schinus terebinthifolia |
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References | Soares DGS (ref19) 2007; 7 Lorenzi H (ref14) 2008 Endo MS (ref8) 2007; 36 Glória LL (ref10) 2017; 22 Chorilli M (ref4) 2009; 30 Kurokawa M (ref12) 1995; 27 Chunasa T (ref5) 2008; 80 Cavalher-Machado SC (ref3) 2008; 8 Tunin LM (ref21) 2016; 54 Pierre SA (ref18) 2009; 14 Baesso ML (ref2) 1994; 4 Guerra MJM (ref11) 2000; 5 Nocchi SR (ref16) 2017; 83 Fatahzadeh M (ref9) 2007; 57 Nocchi SR (ref15) 2016; 12 Spruance SL (ref20) 1977; 297 Arduino PG (ref1) 2008; 37 Nunes-Neto PA (ref17) 2017 Lipipun V (ref13) 2003; 60 Cunningham A (ref6) 2012; 53 De Clercq E (ref7) 2004; 30 Chorilli, M; Tamascia, P; Rossim, C; Salgado, HRN 2009; 30 Chunasa, T; Phromjai, J; Lipipun, V; Likhitwitayawuid, K; Suzuki, M; Pramyothin, P 2008; 80 Pierre, SA; Bartlett, BL; Schlosser, BJ 2009; 14 Nunes-Neto, PA; Peixoto-Sobrinho, TJS; da Silva Júnior, ED; da Silva, JL; Oliveira, ARS; Pupo, AS 2017 Baesso, ML; Snook, RD; Andrews, JJ 1994; 4 De Clercq, E 2004; 30 Spruance, SL; Overall Jr, JC; Kern, ER; Krueger, GG; Pliam, V; Miller, W 1977; 297 Endo, MS; Costa, JV; Natali, MRM; Queiroz, AF 2007; 36 Kurokawa, M; Nagasaka, K; Hirabayashi, T; Uyama, S; Sato, H; Kageyama, T. 1995; 27 Nocchi, SR; Companhoni, MVP; Mello, JCP; Dias Filho, BP; Nakamura, CV; Carollo, CA 2017; 83 Glória, LL; Arantes, MBS; Pereira, SMF; Vieira, GS; Martins, CX; de Carvalho Junior, AR. 2017; 22 Fatahzadeh, M; Schwartz, RA 2007; 57 Arduino, PG; Porter, SR 2008; 37 Lipipun, V; Kurokawa, M; Suttisri, R; Taweechotipatr, P; Pramyothin, P; Hattori, M. 2003; 60 Guerra, MJM; Barreiro, ML; Rodriguez, ZM; Rubaicaba, Y 2000; 5 Lorenzi, H; Matos, FJA 2008 Soares, DGS; Oliveira, CB; Leal, C; Drumind, MRS; Padilha, WWN 2007; 7 Cavalher-Machado, SC; Rosas, EC; Brito, FA; Heringe, AP; Oliveira, RR; Kaplan, MAC 2008; 8 Cunningham, A; Griffiths, P; Leone, P; Mindel, A; Patel, R; Stanberry, L. 2012; 53 Tunin, LM; Borghi, FB; Nogueira, AC; Higachi, L; Barbosa, DS; Baesso, ML 2016; 54 Nocchi, SR; Moura-Costa, GF; Novello, CR; Rodrigues, J; Longhini, R; Mello, JCP 2016; 12 |
References_xml | – volume: 83 start-page: 509 issue: 6 year: 2017 ident: ref16 article-title: Antiviral activitity of crude hydroethanolic extract from Schinus terebinthifolia against Herpes simplex virus type 1 publication-title: Planta Med contributor: fullname: Nocchi SR – volume: 4 start-page: 449 year: 1994 ident: ref2 article-title: Fourier transform infrared photoacoustic spectroscopy to study the penetration of substances through skin publication-title: J Phys IV contributor: fullname: Baesso ML – volume: 5 start-page: 23 issue: 1 year: 2000 ident: ref11 article-title: Actividad antimicrobiana de um extracto fluido al 80% de Schinus terebinthifolius Raddi (copal) publication-title: Rev Cubana Plant Med contributor: fullname: Guerra MJM – volume: 80 start-page: 62 issue: 1 year: 2008 ident: ref5 article-title: Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: Mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice publication-title: Antivir Res doi: 10.1016/j.antiviral.2008.05.002 contributor: fullname: Chunasa T – volume: 57 start-page: 737 issue: 5 year: 2007 ident: ref9 article-title: Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management publication-title: J Am Acad Dermatol doi: 10.1016/j.jaad.2007.06.027 contributor: fullname: Fatahzadeh M – volume: 14 start-page: 1 issue: 8 year: 2009 ident: ref18 article-title: Practical management meansures for patients with recurrent herpes labialis publication-title: Skin Therapy Lett contributor: fullname: Pierre SA – year: 2008 ident: ref14 contributor: fullname: Lorenzi H – volume: 7 start-page: 253 issue: 3 year: 2007 ident: ref19 article-title: Atividade antibacteriana in vitro da tintura de aroeira (Schinus terebinthifolius) na descontaminação de escovas dentais contaminadas pelo S. Mutans publication-title: Pesqui Bras Odontopediatria Clin Integr doi: 10.4034/1519.0501.2007.0073.0010 contributor: fullname: Soares DGS – volume: 22 start-page: 1 issue: 10 year: 2017 ident: ref10 article-title: Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats publication-title: Molecules contributor: fullname: Glória LL – year: 2017 ident: ref17 article-title: The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction publication-title: Evid Based Complement Alternat Med doi: 10.1155/2017/1416375 contributor: fullname: Nunes-Neto PA – volume: 27 start-page: 19 issue: 1-2 year: 1995 ident: ref12 article-title: Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo publication-title: Antivir Res doi: 10.1016/0166-3542(94)00076-K contributor: fullname: Kurokawa M – volume: 37 start-page: 107 issue: 2 year: 2008 ident: ref1 article-title: Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features publication-title: J Oral Pathol Med doi: 10.1111/j.1600-0714.2007.00586.x contributor: fullname: Arduino PG – volume: 8 start-page: 1552 issue: 11 year: 2008 ident: ref3 article-title: The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2008.06.012 contributor: fullname: Cavalher-Machado SC – volume: 12 start-page: 160 issue: 46 year: 2016 ident: ref15 article-title: In vitro Cytotoxicity and Antiherpes Simplex Virus Type 1 Activity of Hydroethanolic Extract, Fractions, and Isolated Compounds from Stem Bark of Schinus terebinthifolius Raddi publication-title: Pharmacog Mag doi: 10.4103/0973-1296.177903 contributor: fullname: Nocchi SR – volume: 60 start-page: 175 issue: 3 year: 2003 ident: ref13 article-title: Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo publication-title: Antivir Res doi: 10.1016/S0166-3542(03)00152-9 contributor: fullname: Lipipun V – volume: 36 start-page: 287 issue: 3 year: 2007 ident: ref8 article-title: Efeito in vivo do etil-cianoacrilato como isolamento absoluto em gengiva inserida publication-title: Rev Odontol. UNESP contributor: fullname: Endo MS – volume: 54 start-page: 139 issue: 1 year: 2016 ident: ref21 article-title: Employing photoacoustic spectroscopy in the evaluation of the skin permeation profile of emulsion containing antioxidant phenolic-rich extract of Melochia arenosa publication-title: Pharm Biol doi: 10.3109/13880209.2015.1021817 contributor: fullname: Tunin LM – volume: 30 start-page: 19 issue: 1 year: 2009 ident: ref4 article-title: Ensaios biológicos para avaliação de segurança de produtos cosméticos publication-title: Rev Cienc Farm Bas Apl contributor: fullname: Chorilli M – volume: 297 start-page: 69 issue: 2 year: 1977 ident: ref20 article-title: The natural history of recurrent herpes simplex labialis: implications for antiviral therapy publication-title: New Engl J Med doi: 10.1056/NEJM197707142970201 contributor: fullname: Spruance SL – volume: 53 start-page: 6 issue: 1 year: 2012 ident: ref6 article-title: Current management and recommendations for acess to antiviral therapy of herpes labialis publication-title: J Clin Virol doi: 10.1016/j.jcv.2011.08.003 contributor: fullname: Cunningham A – volume: 30 start-page: 115 issue: 2 year: 2004 ident: ref7 article-title: Antiviral drugs in current clinical use publication-title: J Clin Virol doi: 10.1016/j.jcv.2004.02.009 contributor: fullname: De Clercq E – volume: 30 start-page: 115 issue: 2 year: 2004 end-page: 133 article-title: Antiviral drugs in current clinical use publication-title: J Clin Virol contributor: fullname: De Clercq, E – volume: 57 start-page: 737 issue: 5 year: 2007 end-page: 763 article-title: Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management publication-title: J Am Acad Dermatol contributor: fullname: Fatahzadeh, M; Schwartz, RA – volume: 27 start-page: 19 issue: 1-2 year: 1995 end-page: 37 article-title: Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo publication-title: Antivir Res contributor: fullname: Kurokawa, M; Nagasaka, K; Hirabayashi, T; Uyama, S; Sato, H; Kageyama, T. – volume: 60 start-page: 175 issue: 3 year: 2003 end-page: 180 article-title: Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo publication-title: Antivir Res contributor: fullname: Lipipun, V; Kurokawa, M; Suttisri, R; Taweechotipatr, P; Pramyothin, P; Hattori, M. – year: 2008 publication-title: Plantas medicinais no Brasil: nativas e exóticas contributor: fullname: Lorenzi, H; Matos, FJA – volume: 22 start-page: 1 issue: 10 year: 2017 end-page: 11 article-title: Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats publication-title: Molecules contributor: fullname: Glória, LL; Arantes, MBS; Pereira, SMF; Vieira, GS; Martins, CX; de Carvalho Junior, AR. – volume: 80 start-page: 62 issue: 1 year: 2008 end-page: 70 article-title: Anti-herpes simplex virus (HSV-1) activity of oxyresveratrol derived from Thai medicinal plant: Mechanism of action and therapeutic efficacy on cutaneous HSV-1 infection in mice publication-title: Antivir Res contributor: fullname: Chunasa, T; Phromjai, J; Lipipun, V; Likhitwitayawuid, K; Suzuki, M; Pramyothin, P – volume: 53 start-page: 6 issue: 1 year: 2012 end-page: 11 article-title: Current management and recommendations for acess to antiviral therapy of herpes labialis publication-title: J Clin Virol contributor: fullname: Cunningham, A; Griffiths, P; Leone, P; Mindel, A; Patel, R; Stanberry, L. – volume: 7 start-page: 253 issue: 3 year: 2007 end-page: 257 article-title: Atividade antibacteriana in vitro da tintura de aroeira (Schinus terebinthifolius) na descontaminação de escovas dentais contaminadas pelo S. Mutans publication-title: Pesqui Bras Odontopediatria Clin Integr contributor: fullname: Soares, DGS; Oliveira, CB; Leal, C; Drumind, MRS; Padilha, WWN – year: 2017 article-title: The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction publication-title: Evid Based Complement Alternat Med contributor: fullname: Nunes-Neto, PA; Peixoto-Sobrinho, TJS; da Silva Júnior, ED; da Silva, JL; Oliveira, ARS; Pupo, AS – volume: 14 start-page: 1 issue: 8 year: 2009 end-page: 3 article-title: Practical management meansures for patients with recurrent herpes labialis publication-title: Skin Therapy Lett contributor: fullname: Pierre, SA; Bartlett, BL; Schlosser, BJ – volume: 12 start-page: 160 issue: 46 year: 2016 end-page: 164 article-title: In vitro Cytotoxicity and Antiherpes Simplex Virus Type 1 Activity of Hydroethanolic Extract, Fractions, and Isolated Compounds from Stem Bark of Schinus terebinthifolius Raddi publication-title: Pharmacog Mag contributor: fullname: Nocchi, SR; Moura-Costa, GF; Novello, CR; Rodrigues, J; Longhini, R; Mello, JCP – volume: 83 start-page: 509 issue: 6 year: 2017 end-page: 518 article-title: Antiviral activitity of crude hydroethanolic extract from Schinus terebinthifolia against Herpes simplex virus type 1 publication-title: Planta Med contributor: fullname: Nocchi, SR; Companhoni, MVP; Mello, JCP; Dias Filho, BP; Nakamura, CV; Carollo, CA – volume: 54 start-page: 139 issue: 1 year: 2016 end-page: 145 article-title: Employing photoacoustic spectroscopy in the evaluation of the skin permeation profile of emulsion containing antioxidant phenolic-rich extract of Melochia arenosa publication-title: Pharm Biol contributor: fullname: Tunin, LM; Borghi, FB; Nogueira, AC; Higachi, L; Barbosa, DS; Baesso, ML – volume: 8 start-page: 1552 issue: 11 year: 2008 end-page: 1560 article-title: The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy publication-title: Int Immunopharmacol contributor: fullname: Cavalher-Machado, SC; Rosas, EC; Brito, FA; Heringe, AP; Oliveira, RR; Kaplan, MAC – volume: 5 start-page: 23 issue: 1 year: 2000 end-page: 25 article-title: Actividad antimicrobiana de um extracto fluido al 80% de Schinus terebinthifolius Raddi (copal) publication-title: Rev Cubana Plant Med contributor: fullname: Guerra, MJM; Barreiro, ML; Rodriguez, ZM; Rubaicaba, Y – volume: 37 start-page: 107 issue: 2 year: 2008 end-page: 121 article-title: Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features publication-title: J Oral Pathol Med contributor: fullname: Arduino, PG; Porter, SR – volume: 297 start-page: 69 issue: 2 year: 1977 end-page: 75 article-title: The natural history of recurrent herpes simplex labialis: implications for antiviral therapy publication-title: New Engl J Med contributor: fullname: Spruance, SL; Overall Jr, JC; Kern, ER; Krueger, GG; Pliam, V; Miller, W – volume: 4 start-page: 449 year: 1994 end-page: 451 article-title: Fourier transform infrared photoacoustic spectroscopy to study the penetration of substances through skin publication-title: J Phys IV contributor: fullname: Baesso, ML; Snook, RD; Andrews, JJ – volume: 36 start-page: 287 issue: 3 year: 2007 end-page: 292 article-title: Efeito in vivo do etil-cianoacrilato como isolamento absoluto em gengiva inserida publication-title: Rev Odontol. UNESP contributor: fullname: Endo, MS; Costa, JV; Natali, MRM; Queiroz, AF – volume: 30 start-page: 19 issue: 1 year: 2009 end-page: 30 article-title: Ensaios biológicos para avaliação de segurança de produtos cosméticos publication-title: Rev Cienc Farm Bas Apl contributor: fullname: Chorilli, M; Tamascia, P; Rossim, C; Salgado, HRN |
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Title | Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection |
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