Egg Protein Transferrin-Derived Peptides Irw (Lle-Arg-Trp) and Iqw (Lle-Gln-Trp) Prevent Obesity Mouse Model Induced by a High-Fat Diet via Reducing Lipid Deposition and Reprogramming Gut Microbiota

• Published in: International journal of molecular sciences Vol. 23; no. 19; p. 11227
• Main Authors: Liu, Zhuangzhuang, Ding, Sujuan, Jiang, Hongmei, Fang, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.09.2022; MDPI
• Subjects: Adiponectin - metabolism; Animals; Blood pressure; Body fat; Cholesterol - pharmacology; Diacylglycerol O-Acyltransferase - metabolism; Diet; Diet, High-Fat - adverse effects; Disease Models, Animal; Egg Proteins - metabolism; Energy; Gastrointestinal Microbiome; Glucose - pharmacology; Gut microbiota; Hypertension; Inflammation; Insulins - metabolism; Interleukin-6 - metabolism; Leptin - metabolism; Lipids; Lipoproteins, HDL - metabolism; Lipoproteins, LDL - metabolism; Liver; Malondialdehyde; Membrane Proteins - metabolism; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Microbiota; Obesity; Obesity - etiology; Oxidation; Oxidative stress; Peptides; Peptides - pharmacology; Proteins; RNA, Messenger; RNA, Ribosomal, 16S - metabolism; Transferrin - pharmacology; Triglycerides - pharmacology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Weight Gain; peptides; lipid determination; gut microbiota; obesity; short chain fatty acids

Egg-derived peptides play important roles in insulin secretion and sensitivity, oxidative stress, and inflammation, suggesting their possible involvement in obesity management. Hence, the aim of this study is to explore the alleviating effects of IRW (lle-Arg-Trp) and IQW (lle-Gln-Trp) on obesity vi...