Amlodipine lowers blood pressure without increasing sympathetic activity or activating the renin-angiotensin system in patients with essential hypertension

• Published in: European journal of clinical pharmacology Vol. 53; no. 3-4; pp. 197 - 201
• Main Authors: SASAGURI, M, MATSUMOTO, N, NODA, K, KOGA, M, KINOSHITA, A, IDEISHI, M, ARAKAWA, K
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 1997; Berlin Springer Nature B.V
• Subjects: Aged; Amlodipine - pharmacology; Amlodipine - therapeutic use; Antihypertensive agents; Biological and medical sciences; Blood pressure; Blood Pressure - drug effects; Calcium Channel Blockers - pharmacology; Cardiovascular system; Female; Humans; Hypertension; Hypertension - drug therapy; Hypertension - physiopathology; Male; Medical research; Medical sciences; Middle Aged; Norepinephrine - blood; Pharmacology. Drug treatments; Renin - blood; Renin-Angiotensin System - drug effects; Sympathetic Nervous System - drug effects; Human; Hypertension; Calcium antagonist; Oral administration; Cardiovascular disease; Slow release form; Catecholamine; Sympathetic nervous system; Renin angiotensin system; Amlodipine; Neurotransmitter; Antihypertensive agent; Dihydropyridine derivatives; Norepinephrine; Mechanism of action

Recent clinical studies suggest that the reflex increase in sympathetic nervous activity accompanying a reduction in blood pressure may contribute to the untoward effects of dihydropyridine calcium antagonists. The aim of this study was to examine whether plasma noradrenaline levels and renin activi...