Secondary metabolites isolated from Richardia brasiliensis Gomes (Rubiaceae)

The family Rubiaceae comprises around 637 genera and approximately 10,700 species, occurring essentially in tropical regions of Brazil. Richardia brasiliensis Gomes, known popularly as "poaia branca", is native to Brazil south region, used in folk medicine as anti-emetic and in the treatme...

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Published inRevista brasileira de farmacognosia Vol. 18; no. 3; pp. 367 - 372
Main Authors Pinto, Danielle S., Tomaz, Anna Cláudia de A., Tavares, Josean F., Tenório-Souza, Fábio H., Dias, Celidarque da Silva, Braz-Filho, Raimundo, da-Cunha, Emídio V. L.
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedade Brasileira de Farmacognosia 01.09.2008
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Abstract The family Rubiaceae comprises around 637 genera and approximately 10,700 species, occurring essentially in tropical regions of Brazil. Richardia brasiliensis Gomes, known popularly as "poaia branca", is native to Brazil south region, used in folk medicine as anti-emetic and in the treatment of diabetes. This work reports the isolation and structural identification of a flavonoid glycoside, a triterpene, a coumarin and two benzoic acid derivatives, aiming at contributing to the chemotaxonomy of the genus Richardia, through a phytochemical study of Richardia brasiliensis. By means of this study the metabolites isorhamnetin-3-O-rutinoside, oleanolic acid, the coumarin scopoletin and p-hydroxy-benzoic and m-methoxy-p-hydroxy-benzoic acids were isolated and identified. All of them, but the latter, were isolated for the first time in the genus, thereby presenting relevant chemotaxonomic importance to it. The structures were identified using spectroscopic techniques such as IR, one and two-dimensional ¹H and 13C NMR besides comparison with literature data.
AbstractList The family Rubiaceae comprises around 637 genera and approximately 10,700 species, occurring essentially in tropical regions of Brazil. Richardia brasiliensis Gomes, known popularly as "poaia branca", is native to Brazil south region, used in folk medicine as anti-emetic and in the treatment of diabetes. This work reports the isolation and structural identification of a flavonoid glycoside, a triterpene, a coumarin and two benzoic acid derivatives, aiming at contributing to the chemotaxonomy of the genus Richardia, through a phytochemical study of Richardia brasiliensis. By means of this study the metabolites isorhamnetin-3-O-rutinoside, oleanolic acid, the coumarin scopoletin and p-hydroxy-benzoic and m-methoxy-p-hydroxy-benzoic acids were isolated and identified. All of them, but the latter, were isolated for the first time in the genus, thereby presenting relevant chemotaxonomic importance to it. The structures were identified using spectroscopic techniques such as IR, one and two-dimensional ¹H and 13C NMR besides comparison with literature data.
Author Braz-Filho, Raimundo
Tenório-Souza, Fábio H.
Dias, Celidarque da Silva
Pinto, Danielle S.
da-Cunha, Emídio V. L.
Tomaz, Anna Cláudia de A.
Tavares, Josean F.
AuthorAffiliation Universidade Federal da Paraíba
Universidade Estadual da Paraíba
Universidade Estadual do Norte Fluminense
AuthorAffiliation_xml – name: Universidade Federal da Paraíba
– name: Universidade Estadual da Paraíba
– name: Universidade Estadual do Norte Fluminense
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  givenname: Danielle S.
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  givenname: Anna Cláudia de A.
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  fullname: Tomaz, Anna Cláudia de A.
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  givenname: Josean F.
  surname: Tavares
  fullname: Tavares, Josean F.
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  givenname: Fábio H.
  surname: Tenório-Souza
  fullname: Tenório-Souza, Fábio H.
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  givenname: Celidarque da Silva
  surname: Dias
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  givenname: Raimundo
  surname: Braz-Filho
  fullname: Braz-Filho, Raimundo
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  givenname: Emídio V. L.
  surname: da-Cunha
  fullname: da-Cunha, Emídio V. L.
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Keywords isorametina-3-O-rutinosídeo
Richardia brasiliensis
oleanolic acid
ácido oleanólico
Rubiaceae
escopoletina
isorhamnetin-3-O-rutinoside
scopoletin
Language English
Portuguese
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Snippet The family Rubiaceae comprises around 637 genera and approximately 10,700 species, occurring essentially in tropical regions of Brazil. Richardia brasiliensis...
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Title Secondary metabolites isolated from Richardia brasiliensis Gomes (Rubiaceae)
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