Lower Antibody Levels to Staphylococcus aureus Exotoxins Are Associated With Sepsis in Hospitalized Adults With Invasive S. aureus Infections

• Published in: The Journal of infectious diseases Vol. 206; no. 6; pp. 915 - 923
• Main Authors: Adhikari, Rajan P., Ajao, Adebola O., Aman, M. Javad, Karauzum, Hatice, Sarwar, Jawad, Lydecker, Alison D., Johnson, J. Kristie, Nguyen, Chinh, Chen, Wilbur H., Roghmann, Mary-Claire
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15.09.2012
• Subjects: Adult; Aged; Antibodies; Antibodies, Bacterial - blood; Bacteremia; BACTERIA; Bacterial Proteins - immunology; Bacteriology; Biological and medical sciences; Cohort Studies; Enterotoxins; Exotoxins; Exotoxins - immunology; Female; Fundamental and applied biological sciences. Psychology; Hospitalization; Humans; Immunoglobulin G - blood; Infections; Infectious diseases; Leukocidins; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Odds Ratio; Risk Factors; Sepsis; Sepsis - immunology; Sepsis - microbiology; Staphylococcal Infections - immunology; Staphylococcal Infections - microbiology; Staphylococcus; Staphylococcus aureus; Staphylococcus aureus - immunology; Staphylococcus aureus - metabolism; Toxins; Infection; Sepsis syndrome; Toxin; Antibody; Bacteria; Micrococcales; Micrococcaceae; Exotoxin; Staphylococcus aureus

Background. Staphylococcus aureus has numerous virulence factors, including exotoxins that may increase the severity of infection. This study was aimed at assessing whether preexisting antibodies to S. aureus toxins are associated with a lower risk of sepsis in adults with S. aureus infection compli...