Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats

• Published in: Thyroid (New York, N.Y.) Vol. 11; no. 8; p. 717
• Main Authors: Safer, J D, Fraser, L M, Ray, S, Holick, M F
• Format: Journal Article
• Language: English
• Published: United States 01.08.2001
• Subjects: Administration, Topical; Animals; Dermis - drug effects; Dermis - growth & development; Dermis - metabolism; Epidermis - drug effects; Epidermis - growth & development; Epidermis - metabolism; Hair - drug effects; Hair - growth & development; Hair - metabolism; Mice; Mice, Hairless; Rats; Rats, Inbred Strains; Skin - drug effects; Skin - growth & development; Skin - metabolism; Thymidine - metabolism; Thyroid Hormones - blood; Triiodothyronine - administration & dosage; Triiodothyronine - pharmacology

The skin is a classic target tissue for thyroid hormone action. Although the histology of skin in hypothyroid states is well documented, the literature contains little assessment of skin in thyrotoxic states. In light of the paucity of information on skin under the influence of excess thyroid hormon...