A Non-Contrast Multi-Parametric MRI Biomarker for Assessment of MR-Guided Focused Ultrasound Thermal Therapies

• Published in: IEEE transactions on biomedical engineering Vol. 71; no. 1; pp. 1 - 12
• Main Authors: Johnson, Sara, Zimmerman, Blake, Odeen, Henrik, Shea, Jill, Winkler, Nicole, Factor, Rachel, Joshi, Sarang, Payne, Allison
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.01.2024; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Ablation; Animals; Biomarkers; Classifiers; Diffusion coefficient; Diffusion Magnetic Resonance Imaging; Focused ultrasound; Histology; histology registration; Histopathology; Humans; Image segmentation; Labels; Lesions; Machine learning; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Measurement; MR-guided; multi-parametric MRI; Necrosis; Neoplasms; Quadriceps muscle; Rabbits; Regression analysis; Supervised learning; Support vector machines; thermal ablation; Tumors; Ultrasonic imaging; Ultrasonography; Ultrasound

Objective: We present the development of a non-contrast multi-parametric magnetic resonance (MPMR) imaging biomarker to assess treatment outcomes for magnetic resonance-guided focused ultrasound (MRgFUS) ablations of localized tumors. Images obtained immediately following MRgFUS ablation were inputs...