Structure–function insights into direct lipid transfer between membranes by Mmm1–Mdm12 of ERMES

• Published in: The Journal of cell biology Vol. 217; no. 3; pp. 959 - 974
• Main Authors: Kawano, Shin, Tamura, Yasushi, Kojima, Rieko, Bala, Siqin, Asai, Eri, Michel, Agnès H., Kornmann, Benoît, Riezman, Isabelle, Riezman, Howard, Sakae, Yoshitake, Okamoto, Yuko, Endo, Toshiya
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 05.03.2018; The Rockefeller University Press
• Subjects: Baking yeast; Biological Transport, Active - physiology; Endoplasmic reticulum; Endoplasmic Reticulum - genetics; Endoplasmic Reticulum - metabolism; Fusion protein; Hydrophobicity; Kluyveromyces - genetics; Kluyveromyces - metabolism; Kluyveromyces lactis; Lipids; Liposomes; Membrane Proteins - genetics; Membrane Proteins - metabolism; Membranes; Mitochondria; Mitochondrial Membranes - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Multiprotein Complexes - genetics; Multiprotein Complexes - metabolism; Mutation; Organelles; Phosphatidylserine; Phospholipids; Phospholipids - genetics; Phospholipids - metabolism; Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Structure-Activity Relationship; Structure-function relationships; Yeast

The endoplasmic reticulum (ER)–mitochondrial encounter structure (ERMES) physically links the membranes of the ER and mitochondria in yeast. Although the ER and mitochondria cooperate to synthesize glycerophospholipids, whether ERMES directly facilitates the lipid exchange between the two organelles...