Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts

• Published in: Molecular Biology and Evolution Vol. 34; no. 12; pp. 3064 - 3080
• Main Authors: Abrahams, Liam, Hurst, Laurence D
• Format: Journal Article Web Resource
• Language: English
• Published: United States Oxford University Press 01.12.2017
• Subjects: Adenine - metabolism; Bacteria - genetics; Base Sequence; Codon - metabolism; Codon, Initiator - genetics; Codon, Terminator - genetics; Discoveries; Evolution, Molecular; Frameshift Mutation - genetics; Genes, Bacterial - genetics; Genome, Bacterial - genetics; Ribosomes - metabolism; RNA Stability - genetics; RNA, Messenger - genetics; error mitigation, dual coding; translation initiation; frameshift; fourth site

Beyond selection for optimal protein functioning, coding sequences (CDSs) are under selection at the RNA and DNA levels. Here, we identify a possible signature of "dual-coding," namely extensive adenine (A) enrichment at bacterial CDS fourth sites. In 99.07% of studied bacterial genomes, f...