Differential responsiveness to cocaine in C57BL/6J and DBA/2J mice

• Published in: Psychopharmacologia Vol. 138; no. 1; pp. 82 - 88
• Main Authors: ROCHA, B. A, ODOM, L. A, BARRON, B. A, ATOR, R, WILD, S. A, FORSTER, M. J
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.07.1998; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Cocaine; Cocaine - metabolism; Cocaine - pharmacology; Conditioning, Operant; Drug addictions; Drug self-administration; Injection; Locomotor activity; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity - drug effects; Narcotics - pharmacology; Operant conditioning; Reinforcement; Self Administration; Toxicology; Intraperitoneal administration; Intravenous administration; Toxicity; Rodentia; Self administration; Locomotion; Vertebrata; Mammalia; Acquisition process; Mouse; Animal; Toxicogenetics; Reinforcement; Genetics; Cocaine; Drug of abuse

The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring Sy...