CXCL8 derived from mesenchymal stromal cells supports survival and proliferation of acute myeloid leukemia cells through the PI3K/AKT pathway

• Published in: The FASEB journal Vol. 33; no. 4; p. 4755
• Main Authors: Cheng, Jingying, Li, Ying, Liu, Shiqi, Jiang, Yajing, Ma, Jiao, Wan, Li, Li, Qinghua, Pang, Tianxiang
• Format: Journal Article
• Language: English
• Published: United States 01.04.2019
• Subjects: Adolescent; Adult; Aged; Apoptosis - drug effects; Blotting, Western; Cell Line, Tumor; Cell Proliferation - genetics; Cell Proliferation - physiology; Cell Survival - drug effects; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescent Antibody Technique; HL-60 Cells; Humans; Interleukin-8 - metabolism; Interleukin-8 - pharmacology; Leukemia, Myeloid, Acute - metabolism; Male; Mesenchymal Stem Cells - metabolism; Middle Aged; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Real-Time Polymerase Chain Reaction; Signal Transduction - drug effects; Young Adult; cancer; cytokines; crosstalk; bone marrow microenvironment

The role of proinflammatory cytokines secreted by the bone marrow mesenchymal stromal cells (BM-MSCs) in the progression of acute myeloid leukemia (AML) is poorly understood. We compared C-X-C motif chemokine ligand (CXCL)8 expression levels in the BM-MSCs of patients with AML and normal control sub...