Interactions between calcium‐induced arrhythmia triggers and the electrophysiological–anatomical substrate underlying the induction of atrial fibrillation

• Published in: The Journal of physiology Vol. 602; no. 5; pp. 835 - 853
• Main Authors: Colman, Michael A., Varela, Marta, MacLeod, Rob S., Hancox, Jules C., Aslanidi, Oleg V.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2024
• Subjects: Action Potentials; Animals; Arrhythmia; atrial fibrillation; Atrial Fibrillation - etiology; atrial remodelling; Calcium; Calcium (reticular); Calcium, Dietary; Cardiac arrhythmia; Cardiac muscle; computational modelling; Dogs; Fibrillation; Fibrosis; Heart Atria; Localization; Membrane potential; Myocytes; Potassium; Pulmonary Veins; Sarcoplasmic reticulum; spontaneous triggers; computational modelling; atrial fibrillation; atrial remodelling; spontaneous triggers; arrhythmia

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is sustained by spontaneous focal excitations and re‐entry. Spontaneous electrical firing in the pulmonary vein (PV) sleeves is implicated in AF generation. The aim of this simulation study was to identify the mechanisms determining...