Feasibility study of using unbalanced embryos as a reference to distinguish euploid carrier from noncarrier embryos by single nucleotide polymorphism array for reciprocal translocations

• Published in: Prenatal diagnosis Vol. 41; no. 6; pp. 681 - 689
• Main Authors: Li, Rong, Wang, Jing, Gu, Ailing, Xu, Yan, Guo, Jing, Pan, Jiafu, Zeng, Yanhong, Ma, Yuanlin, Zhou, Canquan, Xu, Yanwen
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2021
• Subjects: Adult; Arrays; Chromosome translocations; Chromosomes; Diagnosis; Embryo Transfer - methods; Embryos; Feasibility Studies; Female; Gene polymorphism; Genetic screening; Genetic Testing - methods; Heterozygote; Humans; Karyotypes; Male; Nucleotides; Polymorphism; Polymorphism, Single Nucleotide - genetics; Prenatal diagnosis; Single-nucleotide polymorphism; Translocation, Genetic - genetics

Objectives To study the feasibility of using unbalanced embryos as a reference in distinguishing euploid carrier and noncarrier embryos by single nucleotide polymorphism (SNP) array‐based preimplantation genetic testing (PGT) for reciprocal translocations. Methods After comprehensive chromosome scre...