Comparison of grapiprant and meloxicam for management of postoperative joint pain in dogs: A randomized, double‐blinded, prospective clinical trial
Background Grapiprant is a novel anti‐inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs. Objective Compare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs. Animals Forty‐eight dogs presented with cranial cruciat...
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Published in | Journal of veterinary internal medicine Vol. 38; no. 4; pp. 2324 - 2332 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
01.07.2024
Wiley |
Subjects | |
Online Access | Get full text |
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Abstract | Background
Grapiprant is a novel anti‐inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs.
Objective
Compare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs.
Animals
Forty‐eight dogs presented with cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) between May 2020 and May 2022.
Methods
In this randomized, double blinded, prospective clinical trial, client‐owned dogs with naturally occurring unilateral cruciate ligament rupture were enrolled on the day of surgery. The day after surgery, all animals received a subcutaneous injection of 0.2 mg/kg of meloxicam and were randomly assigned to receive either oral grapiprant (2 mg/kg) or meloxicam (0.1 mg/kg), once a day for 14 days, in a blinded manner. The primary endpoint of the study was the pain severity (PSS) and interference (PIS) scores, assessed by the Canine Brief Pain Inventory (CBPI) at day 3, 7, 10 and 15 after the surgery.
Results
Three days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of −0.49 [95% CI −0.94 to −0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in meloxicam group [difference of −0.58 {95% CI −1.03 to −0.13}, P = .013]) and at day 10 (2.23 ± 0.13 vs 2.72 ± 0.28 [difference of −0.49 {95% CI −0.92 to −0.01}, P = .049]).
Conclusions and Clinical Importance
Our study supports the use of grapiprant as an alternative analgesic to meloxicam for management of postoperative joint pain in dogs. |
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AbstractList | Abstract Background Grapiprant is a novel anti‐inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs. Objective Compare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs. Animals Forty‐eight dogs presented with cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) between May 2020 and May 2022. Methods In this randomized, double blinded, prospective clinical trial, client‐owned dogs with naturally occurring unilateral cruciate ligament rupture were enrolled on the day of surgery. The day after surgery, all animals received a subcutaneous injection of 0.2 mg/kg of meloxicam and were randomly assigned to receive either oral grapiprant (2 mg/kg) or meloxicam (0.1 mg/kg), once a day for 14 days, in a blinded manner. The primary endpoint of the study was the pain severity (PSS) and interference (PIS) scores, assessed by the Canine Brief Pain Inventory (CBPI) at day 3, 7, 10 and 15 after the surgery. Results Three days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of −0.49 [95% CI −0.94 to −0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in meloxicam group [difference of −0.58 {95% CI −1.03 to −0.13}, P = .013]) and at day 10 (2.23 ± 0.13 vs 2.72 ± 0.28 [difference of −0.49 {95% CI −0.92 to −0.01}, P = .049]). Conclusions and Clinical Importance Our study supports the use of grapiprant as an alternative analgesic to meloxicam for management of postoperative joint pain in dogs. BackgroundGrapiprant is a novel anti-inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs.ObjectiveCompare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs.AnimalsForty-eight dogs presented with cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) between May 2020 and May 2022.MethodsIn this randomized, double blinded, prospective clinical trial, client-owned dogs with naturally occurring unilateral cruciate ligament rupture were enrolled on the day of surgery. The day after surgery, all animals received a subcutaneous injection of 0.2 mg/kg of meloxicam and were randomly assigned to receive either oral grapiprant (2 mg/kg) or meloxicam (0.1 mg/kg), once a day for 14 days, in a blinded manner. The primary endpoint of the study was the pain severity (PSS) and interference (PIS) scores, assessed by the Canine Brief Pain Inventory (CBPI) at day 3, 7, 10 and 15 after the surgery.ResultsThree days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of −0.49 [95% CI −0.94 to −0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in meloxicam group [difference of −0.58 {95% CI −1.03 to −0.13}, P = .013]) and at day 10 (2.23 ± 0.13 vs 2.72 ± 0.28 [difference of −0.49 {95% CI −0.92 to −0.01}, P = .049]).Conclusions and Clinical ImportanceOur study supports the use of grapiprant as an alternative analgesic to meloxicam for management of postoperative joint pain in dogs. Grapiprant is a novel anti-inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs.BACKGROUNDGrapiprant is a novel anti-inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs.Compare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs.OBJECTIVECompare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs.Forty-eight dogs presented with cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) between May 2020 and May 2022.ANIMALSForty-eight dogs presented with cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) between May 2020 and May 2022.In this randomized, double blinded, prospective clinical trial, client-owned dogs with naturally occurring unilateral cruciate ligament rupture were enrolled on the day of surgery. The day after surgery, all animals received a subcutaneous injection of 0.2 mg/kg of meloxicam and were randomly assigned to receive either oral grapiprant (2 mg/kg) or meloxicam (0.1 mg/kg), once a day for 14 days, in a blinded manner. The primary endpoint of the study was the pain severity (PSS) and interference (PIS) scores, assessed by the Canine Brief Pain Inventory (CBPI) at day 3, 7, 10 and 15 after the surgery.METHODSIn this randomized, double blinded, prospective clinical trial, client-owned dogs with naturally occurring unilateral cruciate ligament rupture were enrolled on the day of surgery. The day after surgery, all animals received a subcutaneous injection of 0.2 mg/kg of meloxicam and were randomly assigned to receive either oral grapiprant (2 mg/kg) or meloxicam (0.1 mg/kg), once a day for 14 days, in a blinded manner. The primary endpoint of the study was the pain severity (PSS) and interference (PIS) scores, assessed by the Canine Brief Pain Inventory (CBPI) at day 3, 7, 10 and 15 after the surgery.Three days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of -0.49 [95% CI -0.94 to -0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in meloxicam group [difference of -0.58 {95% CI -1.03 to -0.13}, P = .013]) and at day 10 (2.23 ± 0.13 vs 2.72 ± 0.28 [difference of -0.49 {95% CI -0.92 to -0.01}, P = .049]).RESULTSThree days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of -0.49 [95% CI -0.94 to -0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in meloxicam group [difference of -0.58 {95% CI -1.03 to -0.13}, P = .013]) and at day 10 (2.23 ± 0.13 vs 2.72 ± 0.28 [difference of -0.49 {95% CI -0.92 to -0.01}, P = .049]).Our study supports the use of grapiprant as an alternative analgesic to meloxicam for management of postoperative joint pain in dogs.CONCLUSIONS AND CLINICAL IMPORTANCEOur study supports the use of grapiprant as an alternative analgesic to meloxicam for management of postoperative joint pain in dogs. Background Grapiprant is a novel anti‐inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs. Objective Compare the efficacy of grapiprant vs meloxicam for the management of postoperative joint pain in dogs. Animals Forty‐eight dogs presented with cranial cruciate ligament disease and treated by tibial plateau leveling osteotomy (TPLO) between May 2020 and May 2022. Methods In this randomized, double blinded, prospective clinical trial, client‐owned dogs with naturally occurring unilateral cruciate ligament rupture were enrolled on the day of surgery. The day after surgery, all animals received a subcutaneous injection of 0.2 mg/kg of meloxicam and were randomly assigned to receive either oral grapiprant (2 mg/kg) or meloxicam (0.1 mg/kg), once a day for 14 days, in a blinded manner. The primary endpoint of the study was the pain severity (PSS) and interference (PIS) scores, assessed by the Canine Brief Pain Inventory (CBPI) at day 3, 7, 10 and 15 after the surgery. Results Three days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of −0.49 [95% CI −0.94 to −0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in meloxicam group [difference of −0.58 {95% CI −1.03 to −0.13}, P = .013]) and at day 10 (2.23 ± 0.13 vs 2.72 ± 0.28 [difference of −0.49 {95% CI −0.92 to −0.01}, P = .049]). Conclusions and Clinical Importance Our study supports the use of grapiprant as an alternative analgesic to meloxicam for management of postoperative joint pain in dogs. |
Author | Kohlhauer, Matthias Cassemiche, Anaelle Manassero, Mathieu Schoffit, Sarah |
AuthorAffiliation | 1 Ecole Nationale Vétérinaire d'Alfort Maisons‐Alfort France 2 Université de Paris, CNRS, INSERM, B3OA Paris France 3 Université Paris Est‐Créteil, INSERM, IMRB Créteil France |
AuthorAffiliation_xml | – name: 3 Université Paris Est‐Créteil, INSERM, IMRB Créteil France – name: 1 Ecole Nationale Vétérinaire d'Alfort Maisons‐Alfort France – name: 2 Université de Paris, CNRS, INSERM, B3OA Paris France |
Author_xml | – sequence: 1 givenname: Anaelle surname: Cassemiche fullname: Cassemiche, Anaelle organization: Ecole Nationale Vétérinaire d'Alfort – sequence: 2 givenname: Sarah surname: Schoffit fullname: Schoffit, Sarah organization: Ecole Nationale Vétérinaire d'Alfort – sequence: 3 givenname: Mathieu surname: Manassero fullname: Manassero, Mathieu organization: Université de Paris, CNRS, INSERM, B3OA – sequence: 4 givenname: Matthias orcidid: 0000-0003-0069-3276 surname: Kohlhauer fullname: Kohlhauer, Matthias email: matthias.kohlhauer@vet-alfort.fr organization: Université Paris Est‐Créteil, INSERM, IMRB |
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article-title: MF498 [N‐{[4‐(5,9‐diethoxy‐6‐oxo‐6,8‐dihydro‐7H‐pyrrolo[3,4‐g]quinolin‐7‐yl)‐3‐methylbenzyl]sulfonyl}‐2‐(2‐methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis publication-title: J Pharmacol Exp Ther – volume: 319 start-page: 1096 year: 2006 end-page: 1103 article-title: Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity publication-title: J Pharmacol Exp Ther – volume: 44 start-page: 705 year: 2021 end-page: 713 article-title: Tolerance and pharmacokinetics of Galliprant™ administered orally to collies homozygous for MDR1‐1Δ publication-title: J Vet Pharmacol Ther – volume: 233 start-page: 1278 year: 2008 end-page: 1283 article-title: Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis publication-title: J Am Vet Med Assoc – volume: 9 year: 2022 article-title: Evaluation of the 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ident: e_1_2_11_2_1 doi: 10.1111/j.1467-2995.2011.00675.x – volume: 261 start-page: 118 year: 2022 ident: e_1_2_11_16_1 article-title: Evaluation of the perioperative analgesic effects of grapiprant compared with carprofen in dogs undergoing elective ovariohysterectomy publication-title: J Am Vet Med Assoc contributor: fullname: Ross JM – ident: e_1_2_11_7_1 doi: 10.1111/jvim.12127 – ident: e_1_2_11_19_1 doi: 10.2460/ajvr.22.03.0036 – ident: e_1_2_11_17_1 doi: 10.2460/ajvr.21.10.0162 – ident: e_1_2_11_25_1 doi: 10.1186/s12917-019-2052-0 – ident: e_1_2_11_3_1 doi: 10.3389/fvets.2017.00083 |
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Snippet | Background
Grapiprant is a novel anti‐inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs.
Objective
Compare the... Abstract Background Grapiprant is a novel anti‐inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs. Objective Compare... BackgroundGrapiprant is a novel anti-inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs.ObjectiveCompare the efficacy... Grapiprant is a novel anti-inflammatory drug approved for the treatment of pain associated with osteoarthritis in dogs.BACKGROUNDGrapiprant is a novel... |
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SubjectTerms | Analgesics Anesthesia anesthesiology Animals Anorexia Anti-inflammatory agents Arthritis Chronic illnesses Clinical trials Diarrhea Dogs evidence based medicine Methadone Nonsteroidal anti-inflammatory drugs Orthopedics Osteoarthritis Pain postoperative pain Quality of life SMALL ANIMAL Surgery Vomiting |
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Title | Comparison of grapiprant and meloxicam for management of postoperative joint pain in dogs: A randomized, double‐blinded, prospective clinical trial |
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