Striated muscle activator of Rho signalling (STARS) overexpression in the mdx mouse enhances muscle functional capacity and regulates the actin cytoskeleton and oxidative phosphorylation pathways

• Published in: Experimental physiology Vol. 106; no. 7; pp. 1597 - 1611
• Main Authors: Sadler, Kate J., Gatta, Paul A. Della, Naim, Timur, Wallace, Marita A., Lee, Albert, Zaw, Thiri, Lindsay, Angus, Chung, Roger S., Bello, Luca, Pegoraro, Elena, Lamon, Séverine, Lynch, Gordon S., Russell, Aaron P.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2021
• Subjects: Actin; actin cytoskeleton; Actin Cytoskeleton - metabolism; adeno‐associated virus; Animals; Calcium; Collagen; Cytoskeleton; Disease Models, Animal; Duchenne's muscular dystrophy; Dystrophin; Dystrophin - genetics; Dystrophin - metabolism; Humans; mdx mouse; Mice; Mice, Inbred mdx; Microfilament Proteins; Mitochondria; Muscle contraction; Muscle function; Muscle, Skeletal - metabolism; muscular dystrophy; Muscular Dystrophy, Duchenne - genetics; Muscular Dystrophy, Duchenne - metabolism; Oxidative Phosphorylation; Oxidative stress; Phosphorylation; Proteins; Proteomics; Quadriceps muscle; RhoA protein; Serum response factor; Signal transduction; Skeletal muscle; STARS; Structure-function relationships; Utrophin; actin cytoskeleton; muscular dystrophy; mdx mouse; STARS; adeno-associated virus; skeletal muscle; oxidative phosphorylation

New Findings What is the central question of this study? Striated muscle activator of rho signalling (STARS) is an actin‐binding protein that regulates transcriptional pathways controlling muscle function, growth and myogenesis, processes that are impaired in dystrophic muscle: what is the regulatio...