Sympathetic Neurostress Drives Osteoblastic Exosomal MiR‐21 Transfer to Disrupt Bone Homeostasis and Promote Osteopenia

• Published in: Small methods Vol. 6; no. 3; pp. e2100763 - n/a
• Main Authors: Hu, Cheng‐Hu, Sui, Bing‐Dong, Liu, Jin, Dang, Lei, Chen, Ji, Zheng, Chen‐Xi, Shi, Songtao, Zhao, Na, Dang, Min‐Yan, He, Xiao‐Ning, Zhang, Li‐Qiang, Gao, Ping‐Ping, Chen, Nan, Kuang, Hui‐Juan, Chen, Kai, Xu, Xiao‐Lin, Yu, Xiao‐Rui, Zhang, Ge, Jin, Yan
• Format: Journal Article
• Language: English
• Published: Germany 01.03.2022
• Subjects: Bone and Bones; Bone Diseases, Metabolic; bones; depression; exosome; Exosomes - genetics; Homeostasis; Humans; microRNA; MicroRNAs - genetics; sympathetic nervous system; microRNA; depression; exosome; bones; sympathetic nervous system

Innervation and extracellular vesicle secretion co‐exist in the local tissue microenvironment for message transfer, but whether they are interconnected to regulate organ homeostasis remains unknown. Sympatho‐adrenergic activation is implicated in stress‐induced depression and leads to bone loss, but...